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Anti-Methyl-hnRNP K-H187 Antibody (CAB18816)

SKU:
CAB18816
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HNRNPK
AUKS
CSBP
HNRPK
TUNP
heterogeneous nuclear ribonucleoprotein K
Research Area:
Immunology
$167 - $587
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Description

Product Name:Methyl-hnRNP K-H187 Rabbit pAb
Product Code:CAB18816
Size:20uL, 50uL, 100uL
Synonyms:HNRNPK, AUKS, CSBP, HNRPK, TUNP, heterogeneous nuclear ribonucleoprotein K
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human Methyl-hnRNP K-H187, 3-methyl (tau-methyl).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:A synthetic peptide of human Methyl-hnRNP K-H187, 3-methyl (tau-methyl).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3190
Uniprot:P61978
Cellular Location:Cell projection, Cytoplasm, Nucleus, nucleoplasm, podosome
Calculated MW:48kDa/50kDa/51kDa
Observed MW:Refer to figures
UniProt Protein Function:hnRNP K: a heterogeneous nuclear ribonucleoprotein (hnRNP). One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:RNA splicing; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 9q21.32

Cellular Component: cell-cell adherens junction; extracellular matrix; focal adhesion; membrane; nuclear chromatin; nucleoplasm; nucleus

Molecular Function:protein binding; RNA binding; single-stranded DNA binding

Biological Process: gene expression; negative regulation of apoptosis; nuclear mRNA splicing, via spliceosome; positive regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of receptor-mediated endocytosis; positive regulation of transcription from RNA polymerase II promoter; protein sumoylation; RNA processing; signal transduction

Disease: Au-kline Syndrome

NCBI Summary:This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]
UniProt Code:P61978
NCBI GenInfo Identifier:48429103
NCBI Gene ID:3190
NCBI Accession:P61978.1
UniProt Secondary Accession:P61978,Q07244, Q15671, Q59F98, Q5T6W4, Q60577, Q922Y7 Q96J62,
UniProt Related Accession:P61978
Molecular Weight:48,562 Da
NCBI Full Name:Heterogeneous nuclear ribonucleoprotein K
NCBI Synonym Full Names:heterogeneous nuclear ribonucleoprotein K
NCBI Official Symbol:HNRNPK  
NCBI Official Synonym Symbols:AUKS; CSBP; TUNP; HNRPK  
NCBI Protein Information:heterogeneous nuclear ribonucleoprotein K
UniProt Protein Name:Heterogeneous nuclear ribonucleoprotein K
UniProt Synonym Protein Names:Transformation up-regulated nuclear protein; TUNP
Protein Family:Heterogeneous nuclear ribonucleoprotein
UniProt Gene Name:HNRNPK  

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