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Anti-Methyl-hnRNP A1-H173 Antibody (CAB18817)

SKU:
CAB18817
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ALS19
ALS20
HNRPA1
HNRPA1L3
IBMPFD3
UP 1
hnRNP A1
hnRNP-A1
UP1
heterogeneous nuclear ribonucleoprotein A1
Research Area:
Immunology
€139 - €489
Frequently bought together:

Description

Product Name:Methyl-hnRNP A1-H173 Rabbit pAb
Product Code:CAB18817
Size:20uL, 50uL, 100uL
Synonyms:HNRNPA1, ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, UP 1, hnRNP A1, hnRNP-A1, hnRNPA1, UP1, heterogeneous nuclear ribonucleoprotein A1
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human Methyl-hnRNP A1-H173, 3-methyl (tau-methyl) .
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:A synthetic peptide of human Methyl-hnRNP A1-H173, 3-methyl (tau-methyl) .
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3178
Uniprot:P09651
Cellular Location:Cytoplasm, Nucleus
Calculated MW:29kDa/34kDa/38kDa
Observed MW:Refer to figures
UniProt Protein Function:hnRNP A1: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication. Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with SEPT6. Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding; RNA splicing; Spliceosome; Nuclear export

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus; ribonucleoprotein complex; spliceosome

Molecular Function:protein binding; RNA binding; single-stranded DNA binding; single-stranded RNA binding

Biological Process: fibroblast growth factor receptor signaling pathway; gene expression; mRNA processing; negative regulation of telomere maintenance via telomerase; nuclear export; nuclear import; nuclear mRNA splicing, via spliceosome; positive regulation of telomere maintenance via telomerase; RNA export from nucleus

Disease: Amyotrophic Lateral Sclerosis 20; Inclusion Body Myopathy With Early-onset Paget Disease With Or Without Frontotemporal Dementia 3

NCBI Summary:This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016]
UniProt Code:P09651
NCBI GenInfo Identifier:288558857
NCBI Gene ID:3178
NCBI Accession:P09651.5
UniProt Secondary Accession:P09651,Q3MIB7, Q6PJZ7, A8K4Z8,
UniProt Related Accession:P09651
Molecular Weight:29,386 Da
NCBI Full Name:Heterogeneous nuclear ribonucleoprotein A1
NCBI Synonym Full Names:heterogeneous nuclear ribonucleoprotein A1
NCBI Official Symbol:HNRNPA1  
NCBI Official Synonym Symbols:UP 1; ALS19; ALS20; HNRPA1; IBMPFD3; HNRPA1L3; hnRNP A1; hnRNP-A1  
NCBI Protein Information:heterogeneous nuclear ribonucleoprotein A1
UniProt Protein Name:Heterogeneous nuclear ribonucleoprotein A1
UniProt Synonym Protein Names:Helix-destabilizing protein; Single-strand RNA-binding protein; hnRNP core protein A1
Protein Family:Heterogeneous nuclear ribonucleoproteins
UniProt Gene Name:HNRNPA1  
UniProt Entry Name:ROA1_HUMAN

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