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Anti-PIR Antibody (CAB20370)

SKU:
CAB20370
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
$311 - $431
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Description

Product Name:PIR Rabbit pAb
Product Code:CAB20370
Size:50uL, 100uL
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human PIR (NP_003653.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human PIR (NP_003653.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8544
Uniprot:O00625
Calculated MW:32kDa
Observed MW:Refer to figures
UniProt Protein Function:PIR: Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro). May interact with NF1/CTF1. Interacts with BCL3. Identified in a complex comprised of PIR, BLC3, NFKB1 and target DNA. Up-regulated in CD34(+) cells upon myelomonocytic differentiation. Down-regulated in many acute myeloid leukemias. Up-regulated in primary bronchial epithelial cells exposed to cigarette smoke extract. Highly expressed in a subset of melanomas. Detected at very low levels in most tissues. Expressed in all tissues, with highest level of expression in heart and liver. Inhibited by kojic acid, sodium diethyldithiocarbamate and 1,10-phenanthroline monohydrochloride. Belongs to the pirin family.
UniProt Protein Details:

Protein type:EC 1.13.11.24; Oxidoreductase; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: Xp22.2

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function:metal ion binding; protein binding; quercetin 2,3-dioxygenase activity; transcription cofactor activity

Biological Process: digestion; monocyte differentiation; regulation of transcription, DNA-templated; transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
UniProt Code:O00625
NCBI GenInfo Identifier:66363697
NCBI Gene ID:8544
NCBI Accession:NP_001018119.1
UniProt Secondary Accession:O00625,Q5U0G0, Q6FHD2,
UniProt Related Accession:O00625
Molecular Weight:32,113 Da
NCBI Full Name:pirin
NCBI Synonym Full Names:pirin
NCBI Official Symbol:PIR  
NCBI Protein Information:pirin
UniProt Protein Name:Pirin
UniProt Synonym Protein Names:Probable quercetin 2,3-dioxygenase PIR; Probable quercetinase
Protein Family:Pirin
UniProt Gene Name:PIR  

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