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Anti-TYRP1 Antibody (CAB20297)

SKU:
CAB20297
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TRP
CAS2
CATB
GP75
OCA3
TRP1
TYRP
b-PROTEIN
€359
Frequently bought together:

Description

Product Name:TYRP1 Rabbit pAb
Product Code:CAB20297
Size:50uL, 100uL
Synonyms:TRP, CAS2, CATB, GP75, OCA3, TRP1, TYRP, b-PROTEIN
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 350-450 of human TYRP1 (NP_000541.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 350-450 of human TYRP1 (NP_000541.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7306
Uniprot:P17643
Calculated MW:60kDa
Observed MW:Refer to figures
UniProt Protein Function:TYRP1: Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3); also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair. Belongs to the tyrosinase family. Protein type: EC 1.14.18.-; Oxidoreductase; Amino Acid Metabolism - tyrosine; Membrane protein, integral Chromosomal Location of Human Ortholog: 9p23 Cellular Component: melanosome membrane; integral to membrane; melanosome; endosome membrane Molecular Function: protein binding; protein homodimerization activity; copper ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen; protein heterodimerization activity Biological Process: melanin biosynthetic process; melanosome organization and biogenesis; melanocyte differentiation; acetoacetic acid metabolic process Disease: Albinism, Oculocutaneous, Type Iii; Skin/hair/eye Pigmentation, Variation In, 11
UniProt Protein Details:
NCBI Summary:This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]
UniProt Code:P17643
NCBI GenInfo Identifier:12644141
NCBI Gene ID:7306
NCBI Accession:P17643.2
UniProt Secondary Accession:P17643,P78468, P78469, Q13721, Q15679
UniProt Related Accession:P17643
Molecular Weight:60,724 Da
NCBI Full Name:5,6-dihydroxyindole-2-carboxylic acid oxidase
NCBI Synonym Full Names:tyrosinase-related protein 1
NCBI Official Symbol:TYRP1  
NCBI Official Synonym Symbols:TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN  
NCBI Protein Information:5,6-dihydroxyindole-2-carboxylic acid oxidase; catalase B; DHICA oxidase; glycoprotein 75; melanoma antigen gp75
UniProt Protein Name:5,6-dihydroxyindole-2-carboxylic acid oxidase
UniProt Synonym Protein Names:Catalase B; Glycoprotein 75; Melanoma antigen gp75; Tyrosinase-related protein 1; TRP; TRP-1; TRP1
Protein Family:5,6-dihydroxyindole-2-carboxylic acid oxidase
UniProt Gene Name:TYRP1  
UniProt Entry Name:TYRP1_HUMAN

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