null

Anti-CCL20 Antibody (CAB1756)

SKU:
CAB1756
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
$167
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-CCL20 Antibody
Antibody SKU:CAB1756
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-95 of human CCL20 (NP_001123518.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:K-562, LO2, A-549, BxPC-3
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-95 of human CCL20 (NP_001123518.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MCCT KSLL LAAL MSVL LLHL CGES EASN FDCC LGYT DRIL HPKF IVGF TRQL ANEG CDIN AIIF HTKK KLSV CANP KQTW VKYI VRLL SKKV KNM
Gene ID:6364
Uniprot:P78556
Cellular Location:Secreted
Calculated MW:10kDa
Observed MW:15kDa
Synonyms:CCL20, CKb4, Exodus, LARC, MIP-3-alpha, MIP-3a, MIP3A, SCYA20, ST38
Background:This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:CCL20: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Chemokine; Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q36.3

Cellular Component: extracellular space; extracellular region

Molecular Function:protein binding; chemokine activity

Biological Process: cell-cell signaling; wound healing; defense response to bacterium; immune response; chemotaxis; inflammatory response; signal transduction; positive regulation of interleukin-1 alpha biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process

NCBI Summary:This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
UniProt Code:P78556
NCBI GenInfo Identifier:2829668
NCBI Gene ID:6364
NCBI Accession:P78556.1
UniProt Secondary Accession:P78556,Q53S51, Q99664,
UniProt Related Accession:P78556
Molecular Weight:10,691 Da
NCBI Full Name:C-C motif chemokine 20
NCBI Synonym Full Names:chemokine (C-C motif) ligand 20
NCBI Official Symbol:CCL20  
NCBI Official Synonym Symbols:CKb4; LARC; ST38; MIP3A; Exodus; MIP-3a; SCYA20; MIP-3-alpha  
NCBI Protein Information:C-C motif chemokine 20; CC chemokine LARC; beta chemokine exodus-1; small-inducible cytokine A20; macrophage inflammatory protein 3 alpha; liver and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 20
UniProt Protein Name:C-C motif chemokine 20
UniProt Synonym Protein Names:Beta-chemokine exodus-1; CC chemokine LARC; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Small-inducible cytokine A20Cleaved into the following 3 chains:CCL20(1-67); CCL20(1-64); CCL20(2-70)
Protein Family:C-C motif chemokine
UniProt Gene Name:CCL20  
UniProt Entry Name:CCL20_HUMAN
Anti-CCL20 Antibody (CAB1756)Western blot analysis of extracts of various cell lines, using CCL20 antibody (CAB1756) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min.

Related Products