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Anti-EDAR Antibody (CAB14105)

SKU:
CAB14105
Product Type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
€139 - €419
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Description

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Antibody Name:Anti-EDAR Antibody
Antibody SKU:CAB14105
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-187 of human EDAR (NP_071731.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Mouse, Rat
Positive Samples:Mouse lung, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-187 of human EDAR (NP_071731.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EYSN CGEN EYYN QTTG LCQE CPPC GPGE EPYL SCGY GTKD EDYG CVPC PAEK FSKG GYQI CRRH KDCE GFFR ATVL TPGD MEND AECG PCLP GYYM LENR PRNI YGMV CYSC LLAP PNTK ECVG ATSG ASAN FPGT SGSS TLSP FQHA HKEL SGQG HLAT A
Gene ID:10913
Uniprot:Q9UNE0
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:48kDa/51kDa
Observed MW:48kDa
Synonyms:EDAR, DL, ECTD10A, ECTD10B, ED1R, ED3, ED5, EDA-A1R, EDA1R, EDA3, HRM1
Background:This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
UniProt Protein Function:EDAR: Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA); also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. Defects in EDAR are the cause of ectodermal dysplasia type 3 (ED3); also known as ectodermal dysplasia hypohidrotic autosomal dominant or EDA3. ED3 is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due to the absence of sweat glands.
UniProt Protein Details:

Protein type:Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q13

Cellular Component: apical part of cell; plasma membrane; integral to membrane

Molecular Function:protein binding; transmembrane receptor activity; receptor activity

Biological Process: epidermis development; pigmentation; hair follicle development; apoptosis; positive regulation of NF-kappaB import into nucleus; cell differentiation; signal transduction; odontogenesis of dentine-containing teeth

Disease: Hair Morphology 1; Ectodermal Dysplasia 10a, Hypohidrotic/hair/nail Type, Autosomal Dominant; Ectodermal Dysplasia 10b, Hypohidrotic/hair/tooth Type, Autosomal Recessive

NCBI Summary:This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UNE0
NCBI GenInfo Identifier:21263572
NCBI Gene ID:10913
NCBI Accession:Q9UNE0.1
UniProt Related Accession:Q9UNE0
Molecular Weight:
NCBI Full Name:Tumor necrosis factor receptor superfamily member EDAR
NCBI Synonym Full Names:ectodysplasin A receptor
NCBI Official Symbol:EDAR  
NCBI Official Synonym Symbols:DL; ED3; ED5; ED1R; EDA3; HRM1; EDA1R; ECTD10A; ECTD10B; EDA-A1R  
NCBI Protein Information:tumor necrosis factor receptor superfamily member EDAR
UniProt Protein Name:Tumor necrosis factor receptor superfamily member EDAR
UniProt Synonym Protein Names:Anhidrotic ectodysplasin receptor 1; Downless homolog; EDA-A1 receptor; Ectodermal dysplasia receptor; Ectodysplasin-A receptor
Protein Family:Tumor necrosis factor receptor superfamily
UniProt Gene Name:EDAR  
UniProt Entry Name:EDAR_HUMAN
Anti-EDAR Antibody (CAB14105)Western blot analysis of extracts of various cell lines, using EDAR antibody (CAB14105) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.

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