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Anti-HCFC1 Antibody (CAB1841)

SKU:
CAB1841
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
$155 - $431
Frequently bought together:

Description

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Antibody Name:Anti-HCFC1 Antibody
Antibody SKU:CAB1841
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human HCFC1 (NP_005325.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HeLa, Jurkat, A-431, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human HCFC1 (NP_005325.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASA VSPA NLPA VLLQ PRWK RVVG WSGP VPRP RHGH RAVA IKEL IVVF GGGN EGIV DELH VYNT ATNQ WFIP AVRG DIPP GCAA YGFV CDGT RLLV FGGM VEYG KYSN DLYE LQAS RWEW KRLK AKTP KNGP PPCP RLGH SFSL VGNK CYLF GGLA NDSE DPKN NIPR YLND LYIL ELRP GSGV VAWD IPIT YGVL PPPR ESHT AVVY TEKD NKKS KLVI YGGM SGCR LGDL WTLD IDTL TWNK PSLS GV
Gene ID:3054
Uniprot:P51610
Cellular Location:Cytoplasm, Nucleus
Calculated MW:47kDa/201kDa/208kDa/213kDa
Observed MW:100-260kDa
Synonyms:HCFC1, CFF, HCF, HCF-1, HCF1, HFC1, MRX3, PPP1R89, VCAF
Background:This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
UniProt Protein Function:HCFC1: Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: nucleoplasm; membrane; cell soma; mitochondrion; cytoplasm; nucleus; histone acetyltransferase complex

Molecular Function:identical protein binding; protein binding; transcription coactivator activity; chromatin binding; histone acetyltransferase activity (H4-K16 specific); transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; establishment and/or maintenance of chromatin architecture; protein stabilization; regulation of transcription, DNA-dependent; organelle organization and biogenesis; reactivation of latent virus; positive regulation of cell cycle; regulation of protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; cell cycle

Disease: Methylmalonic Acidemia And Homocysteinemia, Cblx Type

NCBI Summary:This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Code:P51610
NCBI GenInfo Identifier:160332311
NCBI Gene ID:3054
NCBI Accession:P51610.2
UniProt Secondary Accession:P51610,Q6P4G5,
UniProt Related Accession:P51610,AAB27583
Molecular Weight:2035
NCBI Full Name:Host cell factor 1
NCBI Synonym Full Names:host cell factor C1
NCBI Official Symbol:HCFC1  
NCBI Official Synonym Symbols:CFF; HCF; HCF1; HFC1; MRX3; VCAF; HCF-1; PPP1R89  
NCBI Protein Information:host cell factor 1; VP16-accessory protein; protein phosphatase 1, regulatory subunit 89
UniProt Protein Name:Host cell factor 1
UniProt Synonym Protein Names:C1 factor; CFF; VCAF; VP16 accessory proteinCleaved into the following 12 chains:HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6
Protein Family:Host cell factor
UniProt Gene Name:HCFC1  
UniProt Entry Name:HCFC1_HUMAN

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