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Anti-MUTYH Antibody (CAB1612)

SKU:
CAB1612
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
€129 - €359
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Description

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Antibody Name:Anti-MUTYH Antibody
Antibody SKU:CAB1612
Antibody Size:20uL, 50uL, 100uL
Application:IHC IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-265 of human MUTYH (NP_001041636.1).
Application:IHC IF
Recommended Dilution:IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-265 of human MUTYH (NP_001041636.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTPL VSRL SRLW AIMR KPRA AVGS GHRK QAAS QEGR QKHA KNNS QAKP SACD GLAR QPEE VVLQ ASVS SYHL FRDV AEVT AFRG SLLS WYDQ EKRD LPWR RRAE DEMD LDRR AYAV WVSE VMLQ QTQV ATVI NYYT GWMQ KWPT LQDL ASAS LEEV NQLW AGLG YYSR GRRL QEGA RKVV EELG GHMP RTAE TLQQ LLPG VGRY TAGA IASI AFGQ ATGV VDGN VARV LCRV RAIG ADPS STLV SQQL WGLA QQLV DPAR PGDF N
Gene ID:4595
Uniprot:Q9UIF7
Cellular Location:Nucleus
Calculated MW:57kDa/58kDa/59kDa/60kDa
Observed MW:
Synonyms:MUTYH, MYH
Background:This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7, 8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:MUTYH: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities. Belongs to the Nth/MutY family. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Mitochondrial; DNA repair, damage; Tumor suppressor; Hydrolase; EC 3.2.2.-

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: nucleoplasm; nucleus

Molecular Function:DNA N-glycosylase activity; MutLalpha complex binding; MutLbeta complex binding; MutSalpha complex binding; MutSbeta complex binding; protein binding

Biological Process: depurination; DNA repair; mismatch repair

Disease: Familial Adenomatous Polyposis, 2; Gastric Cancer; Pilomatrixoma

NCBI Summary:This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UIF7
NCBI GenInfo Identifier:48428272
NCBI Gene ID:4595
NCBI Accession:Q9UIF7.1
UniProt Secondary Accession:Q9UIF7,Q15830, Q9UBP2, Q9UBS7, Q9UIF4, Q9UIF5, Q9UIF6 D3DPZ4,
UniProt Related Accession:Q9UIF7
Molecular Weight:57,446 Da
NCBI Full Name:Adenine DNA glycosylase
NCBI Synonym Full Names:mutY DNA glycosylase
NCBI Official Symbol:MUTYH  
NCBI Official Synonym Symbols:MYH  
NCBI Protein Information:adenine DNA glycosylase
UniProt Protein Name:Adenine DNA glycosylase
UniProt Synonym Protein Names:MutY homolog; hMYH
UniProt Gene Name:MUTYH  
UniProt Entry Name:MUTYH_HUMAN
Anti-MUTYH Antibody (CAB1612)Immunofluorescence analysis of U2OS cells using MUTYH antibody (CAB1612). Blue: DAPI for nuclear staining.

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