Recombinant Human SerpinI2 Protein (His Tag) (RPES4785)



ELISA Kit Technical Manual

Recombinant Human SerpinI2 Protein (His Tag)

Background:SERPINI2 is a secreted protein of the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. As protease inhibitors, serpins have an array of functions including regulating blood coagulation, fibrinolysis, the complement pathway, angiogenesis, inflammation, tumor suppression, extracellular matrix remodeling, and cell motility. SERPINI2 is expressed in human tissues including pancreas and adipose tissues. Mutations of human SERPINI2 can directly result in conditions such as acinar cell apoptosis and malabsorption.
Name:Recombinant Human SerpinI2 Protein (His Tag)
Assay Genie SKU:RPES4785
Synonyms:SERPINI2;Serpin I2;Myoepithelium-derived serine protease inhibitor;Pancreas-specific protein TSA2004;Peptidase inhibitor 14;PI4;MEPI;PI14;MEPI;PANCPIN;PI14;TSA2004
Expression host:Human Cells
Mol Mass:45.1 kDa
AP Mol Mass:44-60 kDa
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl,pH7.4.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:SERPINI2: is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: extracellular space

Molecular Function:protein binding

Biological Process: cell motility

NCBI Summary:The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
UniProt Code:O75830
NCBI GenInfo Identifier:20139983
NCBI Gene ID:5276
NCBI Accession:O75830.1
UniProt Related Accession:O75830
Molecular Weight:46,145 Da
NCBI Full Name:Serpin I2
NCBI Synonym Full Names:serpin family I member 2
NCBI Official Symbol:SERPINI2  
NCBI Official Synonym Symbols:MEPI; PI14; PANCPIN; TSA2004  
NCBI Protein Information:serpin I2
UniProt Protein Name:Serpin I2
UniProt Synonym Protein Names:Myoepithelium-derived serine protease inhibitor; Pancpin; Pancreas-specific protein TSA2004; Peptidase inhibitor 14; PI4
Protein Family:Serpin
UniProt Gene Name:SERPINI2  
UniProt Entry Name:SPI2_HUMAN
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Additional Information

Product type:
Recombinant Protein
Host species:
Human Cells
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