SERPINI2 is a secreted protein of the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. As protease inhibitors, serpins have an array of functions including regulating blood coagulation, fibrinolysis, the complement pathway, angiogenesis, inflammation, tumor suppression, extracellular matrix remodeling, and cell motility. SERPINI2 is expressed in human tissues including pancreas and adipose tissues. Mutations of human SERPINI2 can directly result in conditions such as acinar cell apoptosis and malabsorption.
Product Name:
Human SerpinI2 Recombinant Protein (RPES4785)
Product Code:
RPES4785
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
SERPINI2,Serpin I2,Myoepithelium-derived serine protease inhibitor,Pancreas-specific protein TSA2004,Peptidase inhibitor 14,PI-14,MEPI,PI14,MEPI,PANCPIN,PI14,TSA2004
Accession:
O75830
Sequence:
Ser19-Leu405
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Serine Protease Inhibitor-clade I2 is produced by our Mammalian expression system and the target gene encoding Ser19-Leu405 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
45.1 kDa
AP Mol Mass:
44-60 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB,150mM NaCl,pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
