Recombinant Human STXBP3/UNC8C Protein (His & GST Tag) (RPES5155)

SKU:
RPES5155
€402

Description

ELISA Kit Technical Manual

Recombinant Human STXBP3/UNC8C Protein (His & GST Tag)

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Additional Information

Background:Syntaxin-binding protein 3, also known as Platelet Sec1 protein, Protein unc8 homolog 3, Protein unc8 homolog C, Unc8C, Unc18-3 and STXBP3, is a cytoplasm protein which belongs to the STXBP/unc8/SEC1 family. STXBP3 is expressed in cells that exhibit granule exocytosis, such as neutrophils, mast cells, platelets and endothelial cells. STXBP3, together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking / fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. STXBP3 participates in the consolidation and secretion of secondary and tertiary granules. STXBP3 contains one SEC1 domain. Phosphorylation at Ser129 may stimulate granule release. Human STXBP3 shares 90% aa identity with mouse STXBP3. STXBP3 interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion. Interacts with STX4.
Name:Recombinant Human STXBP3/UNC8C Protein (His & GST Tag)
Size:20µg
Assay Genie SKU:RPES5155
Synonyms:MUNC18-3;MUNC18C;PSP;UNC8C
Species:Human
Expression host:Baculovirus-Insect Cells
Sequence:Met 1-Glu 592
Accession:O00186
Mol Mass:95.6 kDa
AP Mol Mass:95.6 kDa
Tag:N-His & GST
Purity:> 82 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.5, 10% glycerol
Reconstitution:Please refer to the printed manual for detailed information.
Product type:
Recombinant Protein
Host species:
Baculovirus-Insect Cells
Reactivity:
Human
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