Anti-SLAMF6 Antibody (CAB10338)

Antibody Name:	Anti-SLAMF6 Antibody
Antibody SKU:	CAB10338
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant protein of human SLAMF6

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	Jurkat, Mouse lung, Mouse spleen, Rat liver

Immunogen:	Recombinant protein of human SLAMF6
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	114836
Uniprot:	Q96DU3
Cellular Location:	Cell membrane, Single-pass type I membrane protein
Calculated MW:	24kDa/37kDa
Observed MW:	70kDa

Synonyms:

SLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000

Background:

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

UniProt Protein Function:	SLAMF6: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q23.2 Cellular Component: plasma membrane Molecular Function:protein binding Biological Process: positive regulation of interferon-gamma production; positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; regulation of immune response
NCBI Summary:	The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
UniProt Code:	Q96DU3
NCBI GenInfo Identifier:	205830927
NCBI Gene ID:	114836
NCBI Accession:	Q96DU3.3
UniProt Secondary Accession:	Q96DU3,Q14CF0, Q5TAS4, Q5TAS6, Q5TAT3, Q96DV0, A6NMW2 B2R8X8,
UniProt Related Accession:	Q96DU3
Molecular Weight:	24,976 Da
NCBI Full Name:	SLAM family member 6
NCBI Synonym Full Names:	SLAM family member 6
NCBI Official Symbol:	SLAMF6
NCBI Official Synonym Symbols:	KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000
NCBI Protein Information:	SLAM family member 6
UniProt Protein Name:	SLAM family member 6
UniProt Synonym Protein Names:	Activating NK receptor; NK-T-B-antigen; NTB-A; CD_antigen: CD352
Protein Family:	SLAM family
UniProt Gene Name:	SLAMF6
UniProt Entry Name:	SLAF6_HUMAN

	Western blot analysis of extracts of Jurkat cells, using SLAMF6 antibody (CAB10338) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
	Western blot analysis of extracts of various cell lines, using SLAMF6 antibody (CAB10338) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)