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Anti-SLC25A6 Antibody (CAB15029)

SKU:
CAB15029
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
$167 - $503
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Description

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Antibody Name:Anti-SLC25A6 Antibody
Antibody SKU:CAB15029
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human SLC25A6 (NP_001627.2).
Application:IF
Recommended Dilution:IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human SLC25A6 (NP_001627.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTEQ AISF AKDF LAGG IAAA ISKT AVAP IERV KLLL QVQH ASKQ IAAD KQYK GIVD CIVR IPKE QGVL SFWR GNLA NVIR YFPT QALN FAFK DKYK QIFL GGVD KHTQ FWRY FAGN LASG GAAG ATSL CFVY PLDF ARTR LAAD VGKS GTER EFRG LGDC LVKI TKSD GIRG LYQG FSVS VQGI IIYR AAYF GVYD TAKG MLPD PKNT HIVV SWMI AQTV TAVA GVVS YPFD TVRR RMMM QSGR KGAD IMYT GTVD CWRK IFRD EGGK AFFK GAWS NVLR GMGG AFVL VLYD ELKK VI
Gene ID:293
Uniprot:P12236
Cellular Location:Mitochondrion inner membrane, Multi-pass membrane protein
Calculated MW:32kDa
Observed MW:
Synonyms:SLC25A6, AAC3, ANT, ANT 2, ANT 3, ANT3, ANT3Y, ANT2
Background:This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene.
UniProt Protein Function:SLC25A6: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. Belongs to the mitochondrial carrier family.
UniProt Protein Details:

Protein type:Transporter; Transporter, SLC family; Mitochondrial; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3

Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane; nucleus; mitochondrial inner membrane presequence translocase complex

Molecular Function:protein binding; ATP:ADP antiporter activity

Biological Process: ATP transport; ADP transport; cellular protein metabolic process; viral reproduction; apoptosis; active induction of host immune response by virus; virus-host interaction; energy reserve metabolic process; viral infectious cycle; regulation of insulin secretion; protein targeting to mitochondrion; transmembrane transport

NCBI Summary:This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]
UniProt Code:P12236
NCBI GenInfo Identifier:113463
NCBI Gene ID:293
NCBI Accession:P12236.4
UniProt Secondary Accession:P12236,Q96C49,
UniProt Related Accession:P12236
Molecular Weight:298
NCBI Full Name:ADP/ATP translocase 3
NCBI Synonym Full Names:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
NCBI Official Symbol:SLC25A6  
NCBI Official Synonym Symbols:2; 3; ANT; AAC3; ANT3; ANT 2; ANT 3; ANT3Y  
NCBI Protein Information:ADP/ATP translocase 3; ADP,ATP carrier protein 3; ADP/ATP translocator of liver; ADP,ATP carrier protein, liver; adenine nucleotide translocator 3; solute carrier family 25 member 6; ADP,ATP carrier protein, isoform T2
UniProt Protein Name:ADP/ATP translocase 3
UniProt Synonym Protein Names:ADP,ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6ADP/ATP translocase 3, N-terminally processed
Protein Family:ADP/ATP translocase
UniProt Gene Name:SLC25A6  
UniProt Entry Name:ADT3_HUMAN
Anti-SLC25A6 Antibody (CAB15029)Immunofluorescence analysis of U2OS cells using SLC25A6 antibody (CAB15029) at dilution of 1:100. Blue: DAPI for nuclear staining.

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