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Anti-UGT2B7 Antibody (CAB1693)

SKU:
CAB1693
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
  • Metabolism Antibodies 2 Anti-UGT2B7 Antibody CAB1693
  • Metabolism Antibodies 2 Anti-UGT2B7 Antibody CAB1693
€139 - €419
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Description

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Antibody Name:Anti-UGT2B7 Antibody
Antibody SKU:CAB1693
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-351 of human UGT2B7 (NP_001065.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, 293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-351 of human UGT2B7 (NP_001065.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KVLV WAAE YSHW MNIK TILD ELIQ RGHE VTVL ASSA SILF DPNN SSAL KIEI YPTS LTKT ELEN FIMQ QIKR WSDL PKDT FWLY FSQV QEIM SIFG DITR KFCK DVVS NKKF MKKV QESR FDVI FADA IFPC SELL AELF NIPF VYSL SFSP GYTF EKHS GGFI FPPS YVPV VMSE LTDQ MTFM ERVK NMIY VLYF DFWF EIFD MKKW DQFY SEVL GRPT TLSE TMGK ADVW LIRN SWNF QFPY PLLP NVDF VGGL HCKP AKPL PKEM EDFV QSSG ENGV VVFS LGSM VSNM TEER ANVI ASAL AQIP QKVL WRFD GNKP DTLG LNT
Gene ID:7364
Uniprot:P16662
Cellular Location:Endoplasmic reticulum membrane, Microsome membrane, Single-pass membrane protein
Calculated MW:60kDa
Observed MW:70kDa
Synonyms:UGT2B7, UDPGT 2B7, UDPGT 2B9, UDPGT2B7, UDPGTH2, UDPGTh-2, UGT2B9, UDPGT2B9
Background:The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3, 4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites.
UniProt Protein Function:UGT2B7: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Belongs to the UDP-glycosyltransferase family.
UniProt Protein Details:

Protein type:Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Carbohydrate Metabolism - pentose and glucuronate interconversions; EC 2.4.1.17; Transferase; Cofactor and Vitamin Metabolism - retinol; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes

Chromosomal Location of Human Ortholog: 4q13

Cellular Component: endoplasmic reticulum membrane; membrane; intracellular membrane-bound organelle; integral to membrane

Molecular Function:retinoic acid binding; glucuronosyltransferase activity

Biological Process: flavonoid biosynthetic process; androgen metabolic process; lipid metabolic process; cellular response to hormone stimulus

NCBI Summary:The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. [provided by RefSeq, Sep 2011]
UniProt Code:P16662
NCBI GenInfo Identifier:136727
NCBI Gene ID:7364
NCBI Accession:P16662.1
UniProt Secondary Accession:P16662,Q6GTW0, B2R810,
UniProt Related Accession:P16662
Molecular Weight:529
NCBI Full Name:UDP-glucuronosyltransferase 2B7
NCBI Synonym Full Names:UDP glucuronosyltransferase 2 family, polypeptide B7
NCBI Official Symbol:UGT2B7  
NCBI Official Synonym Symbols:UGT2B9; UDPGTH2; UDPGT2B7; UDPGT 2B9  
NCBI Protein Information:UDP-glucuronosyltransferase 2B7; UDPGTh-2; UDPGT 2B7; 3,4-catechol estrogen specific; UDP glucuronosyltransferase 2B7; UDP-glucuronosyltransferase 2B9; 3,4-catechol estrogen-specific UDPGT; UDP-glucuronyltransferase, family 2, beta-7
UniProt Protein Name:UDP-glucuronosyltransferase 2B7
UniProt Synonym Protein Names:3,4-catechol estrogen-specific UDPGT; UDP-glucuronosyltransferase 2B9; UDPGT 2B9; UDPGTh-2
Protein Family:UDP-glucuronosyltransferase
UniProt Gene Name:UGT2B7  
UniProt Entry Name:UD2B7_HUMAN
Anti-UGT2B7 Antibody (CAB1693)Western blot analysis of extracts of various cell lines, using UGT2B7 antibody (CAB1693) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-UGT2B7 Antibody (CAB1693)Immunofluorescence analysis of HeLa cells using UGT2B7 Polyclonal Antibody (CAB1693) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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