null

Anti-PTGIS Antibody (CAB20443)

SKU:
CAB20443
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CYP8
PGIS
PTGI
CYP8A1
€259 - €359
Frequently bought together:

Description

Product Name:PTGIS Rabbit pAb
Product Code:CAB20443
Size:50uL, 100uL
Synonyms:CYP8, PGIS, PTGI, CYP8A1
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 151-500 of human PTGIS (NP_000952.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 151-500 of human PTGIS (NP_000952.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5740
Uniprot:Q16647
Calculated MW:57kDa
Observed MW:Refer to figures
UniProt Protein Function:PTGIS: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). Belongs to the cytochrome P450 family.
UniProt Protein Details:

Protein type:Lipid Metabolism - arachidonic acid; Membrane protein, integral; Isomerase; EC 5.3.99.4; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 20q13.13

Cellular Component: extracellular space; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; caveola; nucleus

Molecular Function:protein binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; heme binding; prostaglandin-I synthase activity; monooxygenase activity

Biological Process: positive regulation of angiogenesis; vitamin metabolic process; NAD metabolic process; inhibition of NF-kappaB transcription factor; nicotinamide metabolic process; negative regulation of nitric oxide biosynthetic process; negative regulation of inflammatory response; xenobiotic metabolic process; cyclooxygenase pathway; icosanoid metabolic process; arachidonic acid metabolic process; prostaglandin biosynthetic process; water-soluble vitamin metabolic process

Disease: Hypertension, Essential

NCBI Summary:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
UniProt Code:Q16647
NCBI GenInfo Identifier:2493373
NCBI Gene ID:5740
NCBI Accession:Q16647.1
UniProt Secondary Accession:Q16647,Q3MII8, Q9HAX2, Q9HAX3, Q9HAX4,
UniProt Related Accession:Q16647
Molecular Weight:57,104 Da
NCBI Full Name:Prostacyclin synthase
NCBI Synonym Full Names:prostaglandin I2 (prostacyclin) synthase
NCBI Official Symbol:PTGIS  
NCBI Official Synonym Symbols:CYP8; PGIS; PTGI; CYP8A1  
NCBI Protein Information:prostacyclin synthase; cytochrome P450, family 8, subfamily A, polypeptide 1; prostaglandin I2 synthase
UniProt Protein Name:Prostacyclin synthase
UniProt Synonym Protein Names:Prostaglandin I2 synthase
Protein Family:Prostacyclin receptor
UniProt Gene Name:PTGIS  
UniProt Entry Name:PTGIS_HUMAN

Related Products