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Anti-BDKRB1 Antibody (CAB16777)

SKU:
CAB16777
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
$155
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Description

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Antibody Name:Anti-BDKRB1 Antibody
Antibody SKU:CAB16777
Antibody Size:20uL, 50 uL
Application:IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BDKRB1 (NP_000701.2).
Application:IHC
Recommended Dilution:IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BDKRB1 (NP_000701.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASS WPPL ELQS SNQS QLFP QNAT ACDN APEA WDLL HRVL PTFI ISIC FFGL LGNL FVLL VFLL PRRQ LNVA EIYL ANLA ASDL VFVL GLPF WAEN IWNQ
Gene ID:623
Uniprot:P46663
Cellular Location:
Calculated MW:40kDa
Observed MW:Refer to figures
Synonyms:BDKRB1, B1BKR, B1R, BDKRB2, BKB1R, BKR1, BRADYB1
Background:Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:BKR1: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 14q32.1-q32.2

Cellular Component: endoplasmic reticulum; integral to plasma membrane; plasma membrane

Molecular Function:protein binding

Biological Process: elevation of cytosolic calcium ion concentration

NCBI Summary:Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:P46663
NCBI GenInfo Identifier:85681914
NCBI Gene ID:623
NCBI Accession:P46663.3
UniProt Secondary Accession:P46663,Q546S7, Q8N0Y8, A8K7F5,
UniProt Related Accession:P46663
Molecular Weight:40,495 Da
NCBI Full Name:B1 bradykinin receptor
NCBI Synonym Full Names:bradykinin receptor B1
NCBI Official Symbol:BDKRB1  
NCBI Official Synonym Symbols:B1R; BKR1; B1BKR; BKB1R; BDKRB2; BRADYB1  
NCBI Protein Information:B1 bradykinin receptor
UniProt Protein Name:B1 bradykinin receptor
Protein Family:B1 bradykinin receptor
UniProt Gene Name:BDKRB1  
UniProt Entry Name:BKRB1_HUMAN

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