Anti-CEP170 Antibody (CAB15370)

Antibody Name:	Anti-CEP170 Antibody
Antibody SKU:	CAB15370
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1505-1584 of human CEP170 (NP_055627.2).

Application:	WB
Recommended Dilution:	WB 1:200 - 1:2000
Reactivity:	Human
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1505-1584 of human CEP170 (NP_055627.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	NMGF PSAM LPSP PKQK SSPV NNHH SPGQ TPTL GQPE ARAL HPAA VSAA AEFE NAES EADF SIHF NRFN PDGE EEDV TVQE
Gene ID:	9859
Uniprot:	Q5SW79
Cellular Location:	Cytoplasm, centriole, centrosome, cytoskeleton, microtubule organizing center, spindle
Calculated MW:	161kDa/164kDa/175kDa
Observed MW:	Refer to figures

Synonyms:

CEP170, FAM68A, KAB, KIAA0470

Background:

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.

UniProt Protein Function:	CEP170: a centrosomal protein containing a forkhead associated (FHA) domain. Interacts with Polo-like kinase 1 (PLK1), binds microtubules, and is involved in bundling microtubules.
UniProt Protein Details:	Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 1q44 Cellular Component: centriole; centrosome; microtubule; nuclear membrane; cytoplasm; spindle Molecular Function:protein binding
NCBI Summary:	The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:	Q5SW79
NCBI GenInfo Identifier:	109255230
NCBI Gene ID:	9859
NCBI Accession:	NP_001035863.1
UniProt Secondary Accession:	Q5SW79,O75058, Q5SW77, Q5SW78, Q7LGA9, Q86W31, Q9UQ08 Q9UQ09,
UniProt Related Accession:	Q5SW79
Molecular Weight:	164,539 Da
NCBI Full Name:	centrosomal protein of 170 kDa isoform beta
NCBI Synonym Full Names:	centrosomal protein 170kDa
NCBI Official Symbol:	CEP170
NCBI Official Synonym Symbols:	KAB; FAM68A; KIAA0470
NCBI Protein Information:	centrosomal protein of 170 kDa
UniProt Protein Name:	Centrosomal protein of 170 kDa
UniProt Synonym Protein Names:	KARP-1-binding protein; KARP1-binding protein
Protein Family:	Centrosomal protein
UniProt Gene Name:	CEP170
UniProt Entry Name:	CE170_HUMAN

Antibodies

CEP170 Antibody (PACO06343)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)