Anti-CLCN3 Antibody (CAB17452)

Antibody Name:	Anti-CLCN3 Antibody
Antibody SKU:	CAB17452
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthetic peptide of human CLCN3.

Application:	WB
Recommended Dilution:	WB 1:500 - 1:1000
Reactivity:	Mouse, Rat
Positive Samples:

Immunogen:	A synthetic peptide of human CLCN3.
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	1182
Uniprot:	P51790
Cellular Location:	Cytoplasmic vesicle, Early endosome membrane, Golgi apparatus membrane, Late endosome membrane, Membrane, Multi-pass membrane protein, Multi-pass membrane protein, secretory vesicle membrane
Calculated MW:	88kDa/90kDa/96kDa
Observed MW:	Refer to figures

Synonyms:

CLCN3, CLC3, ClC-3

Background:

This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

NCBI Summary:	This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
UniProt Code:	P51790
NCBI GenInfo Identifier:	226693513
NCBI Gene ID:	1182
NCBI Accession:	P51790.2
UniProt Related Accession:	P51790
Molecular Weight:	88kDa; 90kDa; 96kDa
NCBI Full Name:	H(+)/Cl(-) exchange transporter 3
NCBI Synonym Full Names:	chloride voltage-gated channel 3
NCBI Official Symbol:	CLCN3
NCBI Official Synonym Symbols:	CLC3; ClC-3
NCBI Protein Information:	H(+)/Cl(-) exchange transporter 3
UniProt Protein Name:	H(+)/Cl(-) exchange transporter 3
UniProt Synonym Protein Names:	Chloride channel protein 3; ClC-3; Chloride transporter ClC-3
Protein Family:	H(+)/Cl(-) exchange transporter
UniProt Gene Name:	CLCN3
UniProt Entry Name:	CLCN3_HUMAN

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)