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Anti-COL15A1 Antibody (CAB16820)

SKU:
CAB16820
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€129 - €259
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Description

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Antibody Name:Anti-COL15A1 Antibody
Antibody SKU:CAB16820
Antibody Size:20uL, 50 uL
Application:IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-450 of human COL15A1 (NP_001846.3).
Application:IHC
Recommended Dilution:IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-450 of human COL15A1 (NP_001846.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AGIF MGNA GATG LERF TGSL QQLT VHPD PRTP EELC DPEE SSAS GETS GLQE ADGV AEIL EAVT YTQA SPKE AKVE PINT PPTP SSPF EDME LSGE PVPE GTLE TTNM SIIQ HSSP KQGS GEIL NDTL EGVH SVDG DPIT DSGS GAGA FLDI AEEK NLAA TAAG LAEV PIST AGEA EASS VPTG GPTL SMST ENPE EGVT PGPD NEER LAAT AAGE AEAL ASMP GEVE ASGV APGE LDLS MSAQ SLGE EAT
Gene ID:1306
Uniprot:P39059
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:COL15A1
Background:This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.
UniProt Protein Function:COL15A1: Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. Belongs to the multiplexin collagen family.
UniProt Protein Details:

Protein type:Secreted; Extracellular matrix; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q21-q22

Cellular Component: extracellular matrix; extracellular space; endoplasmic reticulum lumen; collagen type XV; integral to membrane; extracellular region

Molecular Function:extracellular matrix structural constituent

Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; angiogenesis; signal transduction; cell differentiation; cell adhesion

NCBI Summary:This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013]
UniProt Code:P39059
NCBI GenInfo Identifier:119579308
NCBI Gene ID:1306
NCBI Accession:EAW58904.1
UniProt Secondary Accession:P39059,Q5T6J4, Q9UDC5, Q9Y4W4,
UniProt Related Accession:P39059
Molecular Weight:141,720 Da
NCBI Full Name:collagen, type XV, alpha 1, isoform CRA_f
NCBI Synonym Full Names:collagen, type XV, alpha 1
NCBI Official Symbol:COL15A1  
NCBI Protein Information:collagen alpha-1(XV) chain; collagen alpha-1(XV) chain; restin; endostatin-XV; collagen type XV proteoglycan; collagen XV, alpha-1 polypeptide
UniProt Protein Name:Collagen alpha-1(XV) chain
UniProt Synonym Protein Names:Endostatin-XV; Related to endostatin; Restin-IRestin-2; Alternative name(s):; Restin-IIRestin-3; Alternative name(s):; Restin-IIIRestin-4; Alternative name(s):; Restin-IV
Protein Family:Zinc finger protein CONSTANS
UniProt Gene Name:COL15A1  
UniProt Entry Name:COFA1_HUMAN

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