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Anti-DOCK8 Antibody (CAB7998)

SKU:
CAB7998
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€129 - €359
Frequently bought together:

Description

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Antibody Name:DOCK8 Rabbit Polyclonal Antibody
Antibody SKU:CAB7998
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1900-2099 of human DOCK8 (NP_982272.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1900-2099 of human DOCK8 (NP_982272.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TLEG RPRG ELHE QYRR NTVL TTMH AFPY IKTR ISVI QKEE FVLT PIEV AIED MKKK TLQL AVAI NQEP PDAK MLQM VLQG SVGA TVNQ GPLE VAQV FLAE IPAD PKLY RHHN KLRL CFKE FIMR CGEA VEKN KRLI TADQ REYQ QELK KNYN KLKE NLRP MIER KIPE LYKP IFRV ESQK RDSF HRSS FRKC ETQL SQGS
Gene ID:81704
Uniprot:Q8NF50
Cellular Location:
Calculated MW:227kDa/230kDa/235kDa/238kDa
Observed MW:Refer to figures
Synonyms:DOCK8, HEL-205, MRD2, ZIR8
Background:This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
UniProt Protein Function:DOCK8: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Defects in DOCK8 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal recessive (AR-HIES). It is a rare disorder of immunity characterized by immunodeficiency, recurrent infections, eczema, increased serum IgE, eosinophilia and lack of connective tissue and skeletal involvement. Defects in DOCK8 are the cause of mental retardation autosomal dominant type 2 (MRD2). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. A chromosomal aberration disrupting DOCK8 has been found in a patient with mental retardation and ectodermal dysplasia. DOCK8 is disrupted in patients with mental retardation. A balanced translocation, t(X;9) (q13.1;p24). Belongs to the DOCK family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:GEFs; GEFs, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9p24.3

Cellular Component: cytosol; membrane

Molecular Function:protein binding

Biological Process: blood coagulation

Disease: Hyper-ige Recurrent Infection Syndrome, Autosomal Recessive; Mental Retardation, Autosomal Dominant 2

NCBI Summary:This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]
UniProt Code:Q8NF50
NCBI GenInfo Identifier:158937439
NCBI Gene ID:81704
NCBI Accession:Q8NF50.3
UniProt Secondary Accession:Q8NF50,Q3MV16, Q5JPJ1, Q8TEP1, Q8WUY2, Q9BYJ5, Q9H1Q2 A2A350, A2BDF2, A4FU78, B7ZLP0, E9PH09,
UniProt Related Accession:Q8NF50
Molecular Weight:227,477 Da
NCBI Full Name:Dedicator of cytokinesis protein 8
NCBI Synonym Full Names:dedicator of cytokinesis 8
NCBI Official Symbol:DOCK8  
NCBI Official Synonym Symbols:MRD2; ZIR8; HEL-205  
NCBI Protein Information:dedicator of cytokinesis protein 8
UniProt Protein Name:Dedicator of cytokinesis protein 8
Protein Family:Dedicator of cytokinesis protein
UniProt Gene Name:DOCK8  
UniProt Entry Name:DOCK8_HUMAN

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