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Anti-GRM7 Antibody (CAB10488)

SKU:
CAB10488
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€129 - €259
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Description

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Antibody Name:Anti-GRM7 Antibody
Antibody SKU:CAB10488
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 220-410 of human GRM7 (NP_870989.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 220-410 of human GRM7 (NP_870989.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YVST LASE GSYG EKGV ESFT QISK EAGG LCIA QSVR IPQE RKDR TIDF DRII KQLL DTPN SRAV VIFA NDED IKQI LAAA KRAD QVGH FLWV GSDS WGSK INPL HQHE DIAE GAIT IQPK RATV EGFD AYFT SRTL ENNR RNVW FAEY WEEN FNCK LTIS GSKK EDTD RKCT GQER IGKD SNYE QEGK VQF
Gene ID:2917
Uniprot:Q14831
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:101kDa/102kDa/103kDa
Observed MW:Refer to figures
Synonyms:GRM7, GLUR7, GPRC1G, MGLU7, MGLUR7, PPP1R87
Background:L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:mGluR7: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; GPCR, family 3; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p26.1-p25.1

Cellular Component: asymmetric synapse; axon; cell cortex; dendrite; dendritic shaft; integral to membrane; integral to plasma membrane; plasma membrane; postsynaptic membrane; presynaptic active zone; presynaptic membrane; receptor complex

Molecular Function:calcium channel regulator activity; glutamate receptor activity; group III metabotropic glutamate receptor activity

Biological Process: behavioral fear response; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; negative regulation of cAMP biosynthetic process; negative regulation of glutamate secretion; regulation of synaptic transmission, glutamatergic; sensory perception of sound; synaptic transmission

NCBI Summary:L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
UniProt Code:Q14831
NCBI GenInfo Identifier:2495078
NCBI Gene ID:2917
NCBI Accession:Q14831.1
UniProt Secondary Accession:Q14831,Q8NFS2, Q8NFS3, Q8NFS4,
UniProt Related Accession:Q14831
Molecular Weight:101,302 Da
NCBI Full Name:Metabotropic glutamate receptor 7
NCBI Synonym Full Names:glutamate metabotropic receptor 7
NCBI Official Symbol:GRM7  
NCBI Official Synonym Symbols:GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87  
NCBI Protein Information:metabotropic glutamate receptor 7
UniProt Protein Name:Metabotropic glutamate receptor 7
Protein Family:Metabotropic glutamate receptor
UniProt Gene Name:GRM7  
UniProt Entry Name:GRM7_HUMAN

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