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Anti-LTBR Antibody (CAB12006)

SKU:
CAB12006
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
€139 - €419
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Description

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Antibody Name:Anti-LTBR Antibody
Antibody SKU:CAB12006
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 249-435 of human LTBR (NP_002333.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 249-435 of human LTBR (NP_002333.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KSHP SLCR KLGS LLKR RPQG EGPN PVAG SWEP PKAH PYFP DLVQ PLLP ISGD VSPV STGL PAAP VLEA GVPQ QQSP LDLT REPQ LEPG EQSQ VAHG TNGI HVTG GSMT ITGN IYIY NGPV LGGP PGPG DLPA TPEP PYPI PEEG DPGP PGLS TPHQ EDGK AWHL AETE HCGA TPSN RGPR NQFI THD
Gene ID:4055
Uniprot:P36941
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:44kDa/46kDa
Observed MW:47kDa
Synonyms:LTBR, CD18, D12S370, LT-BETA-R, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFR3, TNFRSF3
Background:This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
UniProt Protein Function:LTBR: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to membrane

Molecular Function:identical protein binding; protein binding; ubiquitin protein ligase binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; apoptosis; positive regulation of JNK cascade; myeloid dendritic cell differentiation; signal transduction

NCBI Summary:This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
UniProt Code:P36941
NCBI GenInfo Identifier:549090
NCBI Gene ID:4055
NCBI Accession:P36941.1
UniProt Secondary Accession:P36941,B7Z1D2, D3DUR2, F5GXE7,
UniProt Related Accession:P36941
Molecular Weight:435
NCBI Full Name:Tumor necrosis factor receptor superfamily member 3
NCBI Synonym Full Names:lymphotoxin beta receptor (TNFR superfamily, member 3)
NCBI Official Symbol:LTBR  
NCBI Official Synonym Symbols:CD18; TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III  
NCBI Protein Information:tumor necrosis factor receptor superfamily member 3; lymphotoxin B receptor; tumor necrosis factor C receptor; tumor necrosis factor receptor type III; tumor necrosis factor receptor 2-related protein
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 3
UniProt Synonym Protein Names:Lymphotoxin-beta receptor; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; Tumor necrosis factor receptor type III; TNF-RIII; TNFR-III
Protein Family:Tumor necrosis factor receptor superfamily
UniProt Gene Name:LTBR  
UniProt Entry Name:TNR3_HUMAN
Anti-LTBR Antibody (CAB12006)Western blot analysis of extracts of mouse liver, using LTBR Antibody (CAB12006) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

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