Anti-PDCD10 Antibody (CAB2786)

Antibody Name:	Anti-PDCD10 Antibody
Antibody SKU:	CAB2786
Antibody Size:	20uL, 50uL, 100uL
Application:	IHC
Reactivity:	Human, Rat
Host Species:	Rabbit
Immunogen:	A synthetic peptide of human PDCD10

Application:	IHC
Recommended Dilution:	IHC 1:50 - 1:100
Reactivity:	Human, Rat
Positive Samples:

Immunogen:	A synthetic peptide of human PDCD10
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	11235
Uniprot:	Q9BUL8
Cellular Location:	Cell membrane, Cytoplasm, Cytoplasmic side, Golgi apparatus membrane, Peripheral membrane protein
Calculated MW:	24kDa
Observed MW:

Synonyms:

PDCD10, CCM3, TFAR15

Background:

This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.

UniProt Protein Function:	PDCD10: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3 (CCM3). Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and usually present clinically during the 3rd to 5th decade of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters. Belongs to the PDCD10 family.
UniProt Protein Details:	Protein type:Apoptosis Chromosomal Location of Human Ortholog: 3q26.1 Cellular Component: Golgi membrane; Golgi apparatus; cytoplasm; plasma membrane; cytosol Molecular Function:protein binding; protein homodimerization activity; protein N-terminus binding; protein kinase binding Biological Process: protein stabilization; positive regulation of peptidyl-serine phosphorylation; positive regulation of stress-activated MAPK cascade; positive regulation of MAP kinase activity; response to hydrogen peroxide; establishment of Golgi localization; positive regulation of cell proliferation; stress fiber formation; regulation of Rho protein signal transduction; angiogenesis; positive regulation of Notch signaling pathway; negative regulation of apoptosis; positive regulation of cell migration Disease: Cerebral Cavernous Malformations 3
NCBI Summary:	This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9BUL8
NCBI GenInfo Identifier:	74733232
NCBI Gene ID:	11235
NCBI Accession:	Q9BUL8.1
UniProt Related Accession:	Q9BUL8
Molecular Weight:
NCBI Full Name:	Programmed cell death protein 10
NCBI Synonym Full Names:	programmed cell death 10
NCBI Official Symbol:	PDCD10
NCBI Official Synonym Symbols:	CCM3; TFAR15
NCBI Protein Information:	programmed cell death protein 10
UniProt Protein Name:	Programmed cell death protein 10
UniProt Synonym Protein Names:	Cerebral cavernous malformations 3 protein; TF-1 cell apoptosis-related protein 15
UniProt Gene Name:	PDCD10
UniProt Entry Name:	PDC10_HUMAN

Immunohistochemistry of paraffin-embedded rat spleen using PDCD10 antibody (CAB2786) at dilution of 1:200 (40x lens).

Antibodies

Anti-PDCD10 Antibody (CAB15400)[KO Validated]

Anti-PDCD10 Antibody (CAB17094)

PDCD10 Antibody (PACO11125)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)