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Anti-RIN2 Antibody (CAB17163)

SKU:
CAB17163
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
$155 - $311
Frequently bought together:

Description

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Antibody Name:Anti-RIN2 Antibody
Antibody SKU:CAB17163
Antibody Size:20uL, 50 uL
Application:IF
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 596-895 of human RIN2 (NP_061866.1).
Application:IF
Recommended Dilution:IF 1:50 - 1:200
Reactivity:Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 596-895 of human RIN2 (NP_061866.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HKCI LKPL KGHV EAML KDFH MADG SWKQ LKEN LQLV RQRN PQEL GVFA PTPD FVDV EKIK VKFM TMQK MYSP EKKV MLLL RVCK LIYT VMEN NSGR MYGA DDFL PVLT YVIA QCDM LELD TEIE YMME LLDP SLLH GEGG YYLT SAYG ALSL IKNF QEEQ AARL LSSE TRDT LRQW HKRR TTNR TIPS VDDF QNYL RVAF QEVN SGCT GKTL LVRP YITT EDVC QICA EKFK VGDP EEYS LFLF VDET WQQL AEDT YPQK IKAE LHSR PQPH IFHF VYKR IKND PYGI IFQN GEED LTTS
Gene ID:54453
Uniprot:Q8WYP3
Cellular Location:
Calculated MW:100kDa/105kDa
Observed MW:Refer to figures
Synonyms:RIN2, MACS, RASSF4
Background:The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants.
NCBI Summary:The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
UniProt Code:Q8WYP3
NCBI GenInfo Identifier:18466802
NCBI Gene ID:54453
NCBI Accession:NP_061866
UniProt Related Accession:Q8WYP3
Molecular Weight:
NCBI Full Name:ras and Rab interactor 2 isoform 2
NCBI Synonym Full Names:Ras and Rab interactor 2
NCBI Official Symbol:RIN2  
NCBI Official Synonym Symbols:MACS; RASSF4  
NCBI Protein Information:ras and Rab interactor 2
UniProt Protein Name:Ras and Rab interactor 2
UniProt Synonym Protein Names:Ras association domain family 4; Ras inhibitor JC265; Ras interaction/interference protein 2
Protein Family:Ras and Rab interactor
UniProt Gene Name:RIN2  
UniProt Entry Name:RIN2_HUMAN

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