UniProt Protein Function: | Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling. In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation. |
NCBI Summary: | By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008] |
UniProt Code: | O14796 |
NCBI GenInfo Identifier: | 23503051 |
NCBI Gene ID: | 117157 |
NCBI Accession: | O14796.2 |
UniProt Secondary Accession: | O14796,Q5T0L1, Q8NI18, Q969K9, B2RBN6, |
UniProt Related Accession: | O14796 |
Molecular Weight: | 9,024 Da |
NCBI Full Name: | SH2 domain-containing protein 1B |
NCBI Synonym Full Names: | SH2 domain containing 1B |
NCBI Official Symbol: | SH2D1BÂ Â |
NCBI Official Synonym Symbols: | EAT2Â Â |
NCBI Protein Information: | SH2 domain-containing protein 1B |
UniProt Protein Name: | SH2 domain-containing protein 1B |
UniProt Synonym Protein Names: | EWS/FLI1-activated transcript 2; EAT-2 |
Protein Family: | SH2 domain-containing protein |
UniProt Gene Name: | SH2D1BÂ Â |