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Anti-SHTN1 Antibody (CAB15179)

SKU:
CAB15179
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€129 - €359
Frequently bought together:

Description

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Antibody Name:Anti-SHTN1 Antibody
Antibody SKU:CAB15179
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SHTN1 (NP_001120683.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SHTN1 (NP_001120683.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNSS DEEK QLQL ITSL KEQA IGEY EDLR AENQ KTKE KCDK IRQE RDEA VKKL EEFQ KISH MVIE EVNF MQNH LEIE KTCR ESAE ALAT KLNK ENKT LKRI SMLY MAKL GPDV ITEE INID DEDS TTDT DGAA ETCV SVQC QKQI KELR DQIV SVQE EKKI LAIE LENL KSKL VEVI EEVN KVKQ EKTV LNSE VLEQ RKVL EKCN RVSM LAVE EYEE MQVN LELE KDLR KKAE SFAQ EMFI EQNK LKRQ SHLL LQSS IPDQ QLLK ALDE NAKL TQQL EEER IQHQ QKVK ELEE QLEN ETLH
Gene ID:57698
Uniprot:A0MZ66
Cellular Location:Cell projection, Cytoplasm, Perikaryon, axon, cytoskeleton, filopodium, growth cone, lamellipodium
Calculated MW:23kDa, 52- 73kDa
Observed MW:Refer to figures
Synonyms:SHTN1, KIAA1598, shootin-1
Background:
UniProt Protein Function:Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.
UniProt Code:A0MZ66
NCBI GenInfo Identifier:187761324
NCBI Gene ID:57698
NCBI Accession:NP_001120683.1
UniProt Secondary Accession:A0MZ66,Q68DG1, Q6PIM5, Q9HCH4, A8MYU7, B3KRD3, B3KRH2 B3KTE0, B3KTJ7, B3KTJ8, B4E3U1, B7Z7Z9,
UniProt Related Accession:A0MZ66
Molecular Weight:23kDa, 52-73kDa
NCBI Full Name:shootin-1 isoform a
NCBI Synonym Full Names:shootin 1
NCBI Official Symbol:SHTN1  
NCBI Official Synonym Symbols:KIAA1598; shootin-1  
NCBI Protein Information:shootin-1
UniProt Protein Name:Shootin-1
UniProt Synonym Protein Names:Shootin1
Protein Family:Shootin
UniProt Gene Name:SHTN1  

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