Anti-TLE3 Antibody (CAB17539)

Antibody Name:	Anti-TLE3 Antibody
Antibody SKU:	CAB17539
Antibody Size:	20uL, 50 uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 158-240 of human TLE3 (NP_005069.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 158-240 of human TLE3 (NP_005069.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	PVTG SSSG LLAL GALG SQAH LTVK DEKN HHEL DHRE RESS ANNS VSPS ESLR ASEK HRGS ADYS MEAK KRKA EEKD SLSR YDS
Gene ID:	7090
Uniprot:	Q04726
Cellular Location:
Calculated MW:	82kDa/83kDa
Observed MW:	Refer to figures

Synonyms:

ESG, ESG3, GRG3, HsT18976, TLE3

Background:

This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

UniProt Protein Function:	TLE3: transcriptional corepressor that binds to a number of transcription factors. Belongs to the WD-repeat Groucho/TLE family. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Four alternatively spliced isoforms have been described.
UniProt Protein Details:	Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 15q22 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding Biological Process: Notch signaling pathway; organ morphogenesis; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; signal transduction
NCBI Summary:	This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
UniProt Code:	Q04726
NCBI GenInfo Identifier:	20532417
NCBI Gene ID:	7090
NCBI Accession:	Q04726.2
UniProt Related Accession:	Q04726
Molecular Weight:	82kDa; 83kDa
NCBI Full Name:	Transducin-like enhancer protein 3
NCBI Synonym Full Names:	TLE family member 3, transcriptional corepressor
NCBI Official Symbol:	TLE3
NCBI Official Synonym Symbols:	ESG; ESG3; GRG3; HsT18976
NCBI Protein Information:	transducin-like enhancer protein 3
UniProt Protein Name:	Transducin-like enhancer protein 3
UniProt Synonym Protein Names:	Enhancer of split groucho-like protein 3; ESG3
Protein Family:	Transducin-like enhancer protein
UniProt Gene Name:	TLE3
UniProt Entry Name:	TLE3_HUMAN

Antibodies

TLE3 Antibody (PACO12775)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)