The PER3 Polyclonal Antibody (CAB2219) is a valuable tool for researchers studying PER3, a circadian clock gene that plays a crucial role in regulating the body's internal clock and sleep-wake cycles. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.PER3 is a key player in the circadian rhythm, influencing the timing of sleep and wakefulness as well as other biological processes. Dysregulation of PER3 has been linked to sleep disorders, mood disorders, and other health issues related to disrupted sleep patterns.
By targeting PER3 with this antibody, researchers can better understand its function and potential therapeutic implications in these areas of study.With its high reactivity and specificity, the PER3 Polyclonal Antibody (CAB2219) is an essential tool for researchers exploring the role of PER3 in circadian biology, sleep disorders, and related conditions. Its ability to detect and analyze PER3 protein levels in various cell types makes it a valuable asset for advancing research in this field.
Product Name:
PER3 Rabbit Monoclonal Antibody
SKU:
CAB2219
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 10-100 of human PER3 (P56645).
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8863
Clone Number:
ARC1893
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using PER3 Rabbit mAb (CAB2219) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
