CCR3 Antibody, FITC conjugated (PACO52944)
- SKU:
- PACO52944
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
| Antibody Name: | CCR3 Antibody, FITC conjugated (PACO52944) |
| Antibody SKU: | PACO52944 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human C-C chemokine receptor type 3 protein (306-355AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | FITC |
| Background: | Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. |
| Synonyms: | C-C chemokine receptor type 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193), CCR3, CMKBR3 |
| UniProt Protein Function: | CCR3: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Receptor, cytokine; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR Chromosomal Location of Human Ortholog: 3p21.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:chemokine receptor activity; protein binding Biological Process: cell adhesion; cellular defense response; elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to cAMP nucleotide second messenger; positive regulation of angiogenesis |
| NCBI Summary: | The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009] |
| UniProt Code: | P51677 |
| NCBI GenInfo Identifier: | 1705892 |
| NCBI Gene ID: | 1232 |
| NCBI Accession: | P51677.1 |
| UniProt Secondary Accession: | P51677,Q15748, Q2YDB9, Q86WD2, Q8TDP6, Q9ULY8, B3KVQ1 F5GWL6, |
| UniProt Related Accession: | P51677 |
| Molecular Weight: | 43,453 Da |
| NCBI Full Name: | C-C chemokine receptor type 3 |
| NCBI Synonym Full Names: | C-C motif chemokine receptor 3 |
| NCBI Official Symbol: | CCR3 |
| NCBI Official Synonym Symbols: | CKR3; CD193; CMKBR3; CC-CKR-3 |
| NCBI Protein Information: | C-C chemokine receptor type 3 |
| UniProt Protein Name: | C-C chemokine receptor type 3 |
| UniProt Synonym Protein Names: | Eosinophil eotaxin receptor; CD_antigen: CD193 |
| Protein Family: | C-C chemokine receptor |
| UniProt Gene Name: | CCR3 |
| UniProt Entry Name: | CCR3_HUMAN |
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