The COL6A6 Polyclonal Antibody (PAC035026) is a valuable tool for researchers studying COL6A6, a member of the collagen VI family known for its role in extracellular matrix formation and tissue structure. This antibody, generated in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the COL6A6 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential asset for investigations in the fields of tissue engineering and musculoskeletal biology.
COL6A6 is a crucial component of the extracellular matrix, contributing to the strength and elasticity of connective tissues like tendons, ligaments, and skin. Dysregulation of COL6A6 expression has been associated with various musculoskeletal disorders, making it a promising target for therapeutic interventions aimed at restoring tissue integrity and function. Researchers aiming to delve into the molecular mechanisms underlying these conditions will benefit from the use of this COL6A6 antibody in their experiments.
Antibody Name:
COL6A6 Antibody (PACO35026)
Antibody SKU:
PACO35026
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Collagen alpha-6(VI) chain protein (430-982AA)
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO35026 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO35026 at dilution of 1:100.
Background:
Collagen VI acts as a cell-binding protein.
Synonyms:
Collagen alpha-6(VI) chain, COL6A6
UniProt Protein Function:
COL6A6: Collagen VI acts as a cell-binding protein. Belongs to the type VI collagen family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 3q22.1Cellular Component: extracellular region; proteinaceous extracellular matrixBiological Process: collagen catabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a large protein that contains multiple von Willebrand factor domains and forms a component of the basal lamina of epithelial cells. This protein may regulate epithelial cell-fibronectin interactions. Variation in this gene may be implicated in skin diseases. [provided by RefSeq, May 2017]
