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Kng1 Antibody (PACO27837)

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SKU:
PACO27837
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€359

Description

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Kng1 Antibody (PACO27837)

The KNG1 Polyclonal Antibody (PACO27837) is a valuable tool for researchers studying the kininogen-1 (KNG1) protein, which is involved in the regulation of blood coagulation and inflammation. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is optimized for Western blot applications.KNG1, also known as high molecular weight kininogen, plays a crucial role in the kallikrein-kinin system, which is linked to various physiological and pathological processes. By targeting the KNG1 protein, researchers can investigate its functions in blood clotting, inflammation, and vascular permeability.

The KNG1 Polyclonal Antibody is ideal for studies in hemostasis, thrombosis, and vascular biology, providing valuable insights into the mechanisms underlying these processes. Its specificity and sensitivity make it a reliable tool for exploring the role of KNG1 in health and disease, offering new possibilities for therapeutic interventions targeting the kallikrein-kinin system.

Antibody Name:Kng1 Antibody (PACO27837)
Antibody SKU:PACO27837
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Rat
Immunogen:Recombinant Rat Kininogen-1 protein (2-110AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
Synonyms:Kininogen-1 [Cleaved into: Kininogen-1 heavy chain; Bradykinin; Kininogen-1 light chain], Kng1, Kng
UniProt Protein Function:Function: 1 Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
UniProt Protein Details:
NCBI Summary:precursor protein of kinin which is found in plasma; cysteine protease inhibitor and a major acute phase reactant [RGD, Feb 2006]
UniProt Code:P08934
NCBI GenInfo Identifier:7549773
NCBI Gene ID:25087
NCBI Accession:NP_036873.1
UniProt Secondary Accession:P08934
UniProt Related Accession:P08934
Molecular Weight:
NCBI Full Name:kininogen-1 isoform 1
NCBI Synonym Full Names:kininogen 2-like 1
NCBI Official Symbol:Kng2l1  
NCBI Official Synonym Symbols:Kng1; Kng2; Kngk; KINKG; KINKH; kininogen  
NCBI Protein Information:kininogen-1
UniProt Protein Name:Kininogen-1
UniProt Synonym Protein Names:
Protein Family:
UniProt Gene Name:Kng1  
UniProt Entry Name:KNG1_RAT

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