The LMO3 Polyclonal Antibody (PACO39178) is a valuable tool for researchers studying the LIM domain only 3 (LMO3) protein, which plays a crucial role in various cellular processes, including cell differentiation and proliferation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been rigorously validated for use in Western blot applications.With its ability to specifically bind to the LMO3 protein, this antibody allows for accurate detection and analysis of LMO3 expression in different cell types, making it ideal for investigations in fields such as developmental biology, cancer research, and neurobiology.
The LMO3 protein is known to be involved in the regulation of gene expression and cell growth, making it a promising target for understanding the molecular mechanisms underlying various diseases.By using the LMO3 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of the LMO3 protein, paving the way for potential therapeutic interventions targeting LMO3-related pathways in diseases such as cancer and neurological disorders. Its high specificity and reliability make it a valuable asset for any laboratory conducting research in the field of molecular biology and biomedicine.
Western blot. All lanes: LMO3 antibody at 6µg/ml + Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 17, 20, 18, 19 kDa. Observed band size: 17 kDa.
Immunohistochemistry of paraffin-embedded human colon tissue using PACO39178 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO39178 at dilution of 1:100.
Background:
cytoplasm, negative regulation of ERK1 and ERK2 cascade, positive regulation of fat cell differentiation, positive regulation of glucocorticoid receptor signaling pathway, positive regulation of peroxisome proliferator activated receptor signaling pathway
Synonyms:
LIM domain only protein 3 (LMO-3) (Neuronal-specific transcription factor DAT1) (Rhombotin-3), LMO3, RBTN3 RBTNL2 RHOM3
UniProt Protein Function:
LMO3: 3 isoforms of the human protein are produced by alternative splicing
UniProt Protein Details:
Chromosomal Location of Human Ortholog: 12p12.3
Cellular Component: cytoplasm
Molecular Function:protein binding; zinc ion binding
Biological Process: positive regulation of fat cell differentiation; regulation of transcription, DNA-dependent; transcription, DNA-dependent
NCBI Summary:
The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
