The MAGI2 Polyclonal Antibody (PACO05831) is a valuable tool for researchers studying MAGI2, a protein involved in cell signaling and cell adhesion processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the MAGI2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it well-suited for research in cell biology and cancer studies.MAGI2, also known as membrane-associated guanylate kinase, plays a crucial role in organizing protein complexes at cell junctions and regulating intracellular signaling pathways.
Its involvement in cell adhesion and signal transduction processes makes it a key player in various cellular functions and cellular communication. Research on MAGI2 is essential for understanding its role in health and disease, particularly in cancer progression and metastasis.Overall, the MAGI2 Polyclonal Antibody (PACO05831) is a reliable tool for researchers investigating the function and regulation of MAGI2 in biological processes, providing valuable insights into cell signaling mechanisms and potential therapeutic targets for cancer and other diseases.
Antibody Name:
MAGI2 Antibody (PACO05831)
Antibody SKU:
PACO05831
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the Internal region of human MAGI-2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MAGI2; ACVRINP1; AIP1; KIAA0705; Membrane-associated guanylate kinase; WW and PDZ domain-containing protein 2; Atrophin-1-interacting protein 1; AIP-1; Atrophin-1-interacting protein A; Membrane-associated guanylate kinase inverted 2; MAGI-
UniProt Protein Function:
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
