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Human HMGB1 Recombinant Protein (RPES0717)

SKU:
RPES0717
Product Type:
Recombinant Protein
Host Species:
Human Cells
Reactivity:
Human
€265
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Description

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Human HMGB1 Recombinant Protein

High mobility group protein B1 is a member of the HMGB family consisting of three members; HMGB1; HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein; HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile; it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte; T cell; dendritic cell activities in inflammatory responses.