The TRIM40 Polyclonal Antibody (PAC020359) is a valuable tool for researchers studying TRIM40, a protein involved in immune response regulation. This antibody is raised in rabbits and has high reactivity with human samples, making it ideal for Western blot applications. By binding to the TRIM40 protein, this antibody enables the detection and analysis of TRIM40 in various cell types, making it a valuable tool for studies in immunology and cancer research.TRIM40 is a crucial player in immune regulation, influencing inflammatory responses and allergic reactions.
Understanding the role of TRIM40 in immune modulation is key to advancing research on diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. This antibody provides researchers with the means to investigate TRIM40 activity, paving the way for the development of targeted therapies that manipulate immune function in disease contexts.
Antibody Name:
TRIM40 Antibody (PACO20359)
Antibody SKU:
PACO20359
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human TRIM40
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20359(TRIM40 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20359(TRIM40 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the tripartite motif (TRIM) protein family. The encoded protein may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract. Alternatively spliced transcript variants that encode different protein isoforms have been described.
Synonyms:
tripartite motif containing 40
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
