The VPS41 Polyclonal Antibody (PAC013195) is a valuable tool for researchers studying the VPS41 protein, which plays a crucial role in intracellular trafficking and membrane fusion processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blotting applications.VPS41 is a key component of the HOPS complex, responsible for regulating endosome maturation and lysosome biogenesis. Dysregulation of VPS41 has been associated with various diseases, including lysosomal storage disorders and neurodegenerative diseases.
By targeting VPS41 with this antibody, researchers can better understand its role in cellular processes and potentially uncover new therapeutic strategies for related disorders.Overall, the VPS41 Polyclonal Antibody is a reliable tool for investigating the function of the VPS41 protein in various cell types and biological contexts, making it ideal for research in cell biology, neurology, and metabolism. Its specificity and sensitivity make it a valuable addition to any laboratory conducting studies on intracellular trafficking mechanisms and related diseases.
vacuolar protein sorting 41 homolog (S. cerevisiae);VPS41;HVPS41;HVSP41;hVps41p ;
UniProt Protein Function:
VPS41: Required for vacuolar assembly and vacuolar traffic. Belongs to the VPS41 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating system; VesicleChromosomal Location of Human Ortholog: 7p14-p13Cellular Component: clathrin-coated vesicle; endosome membrane; late endosome membrane; lysosomal membraneMolecular Function: GTPase binding; identical protein binding; protein bindingBiological Process: endosomal vesicle fusion; endosome to lysosome transport; protein targeting to vacuole; vacuole fusion, non-autophagic
UniProt Protein Details:
NCBI Summary:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. [provided by RefSeq, Jul 2008]
