The ZNF146 Polyclonal Antibody (PAC020960) is a crucial tool for research involving ZNF146, a zinc finger protein involved in gene regulation and transcriptional control. This antibody, generated in rabbits, exhibits high specificity and sensitivity for ZNF146 in human samples, making it a reliable choice for Western blot applications.ZNF146 is a key player in the regulation of gene expression, impacting various cellular processes such as cell growth, differentiation, and development. By targeting ZNF146 with this antibody, researchers can delve into its functions in different cell types and gain insights into its role in various biological pathways.
With its ability to accurately detect and analyze ZNF146 protein levels, this antibody is an essential resource for studies in molecular biology, genetics, and epigenetics. By understanding the functions of ZNF146, researchers can uncover potential therapeutic targets for diseases related to dysregulated gene expression, such as cancer, genetic disorders, and developmental abnormalities.
Antibody Name:
ZNF146 Antibody (PACO20960)
Antibody SKU:
PACO20960
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human ZNF146
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO20960(ZNF146 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
ZNF146 (zinc finger protein 146), also known as OZF (only zinc finger protein), is a 292 amino acid, nuclear protein that binds DNA and belongs to the Kr¼ppel C2H2-type zinc-finger protein family. ZNF146 interacts with UBC9 (ubiquitin carrier protein 9) and RAP1 (repressor/activator protein 1 homolog), and is highly expressed in multiple pancreatic and colorectal cancers. Lower levels of expression have been observed in kidney, lung, placenta and brain.
Synonyms:
zinc finger protein 146
UniProt Protein Function:
ZNF146: Belongs to the krueppel C2H2-type zinc-finger protein family.Protein type: DNA-binding; C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 19q13.1Cellular Component: cytoplasm; nucleolus; nucleusMolecular Function: heparin binding; transcription factor activity; zinc ion bindingBiological Process: regulation of transcription, DNA-dependent
