API5 Antibody (PACO06256)
- SKU:
- PACO06256
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | API5 Antibody (PACO06256) |
| Antibody SKU: | PACO06256 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from the C-terminal region of human API5. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of NIH-3T3 cells using API5 Polyclonal Antibody. |
 | Western Blot analysis of HuvEc cells using API5 Polyclonal Antibody. |
| Synonyms: | API5; MIG8; Apoptosis inhibitor 5; API-5; Antiapoptosis clone 11 protein; AAC-11; Cell migration-inducing gene 8 protein; Fibroblast growth factor 2-interacting factor; FIF; Protein XAGL |
| UniProt Protein Function: | API5: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Belongs to the API5 family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; Apoptosis Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: nucleoplasm; spliceosome; membrane; cytoplasm; nucleus Molecular Function:protein binding; fibroblast growth factor binding Biological Process: apoptosis; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9BZZ5 |
| NCBI GenInfo Identifier: | 353526346 |
| NCBI Gene ID: | 8539 |
| NCBI Accession: | Q9BZZ5.3 |
| UniProt Secondary Accession: | Q9BZZ5,O15441, Q9Y4J7, B4DGR0, B4DRJ2, D3DR21, |
| UniProt Related Accession: | Q9BZZ5 |
| Molecular Weight: | 50,740 Da |
| NCBI Full Name: | Apoptosis inhibitor 5 |
| NCBI Synonym Full Names: | apoptosis inhibitor 5 |
| NCBI Official Symbol: | API5 |
| NCBI Official Synonym Symbols: | AAC11; AAC-11 |
| NCBI Protein Information: | apoptosis inhibitor 5; FIF; antiapoptosis clone 11 protein; migration-inducing protein MIG8; cell migration-inducing gene 8 protein; fibroblast growth factor 2-interacting factor 2 |
| UniProt Protein Name: | Apoptosis inhibitor 5 |
| UniProt Synonym Protein Names: | Antiapoptosis clone 11 protein; AAC-11; Cell migration-inducing gene 8 protein; Fibroblast growth factor 2-interacting factor; FIF; Protein XAGL |
| Protein Family: | Apoptosis inhibitor |
| UniProt Gene Name: | API5 |
| UniProt Entry Name: | API5_HUMAN |
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