The HRK Polyclonal Antibody (PAC019793) is a valuable tool for researchers studying the HRK protein, a member of the Bcl-2 family involved in apoptosis regulation. This antibody, generated in rabbits, has high specificity and sensitivity for detecting HRK in human samples, making it ideal for use in Western blot experiments. By binding to the HRK protein, this antibody enables precise detection and analysis in various cell types, making it a valuable asset for studies in cell biology and cancer research.The HRK protein is known for its function in promoting apoptosis, or programmed cell death, in response to cellular stress signals. Dysregulation of apoptosis pathways, including those involving HRK, has been implicated in various diseases, including cancer and neurodegenerative disorders.
Understanding the mechanisms by which HRK operates is crucial for developing targeted therapies that exploit apoptotic pathways to treat these conditions.Overall, the HRK Polyclonal Antibody (PAC019793) is a crucial tool for researchers investigating the role of HRK in apoptosis and its potential as a therapeutic target in disease. Its high specificity and reactivity in human samples make it a valuable asset for advancing our understanding of cell death mechanisms and developing novel treatment strategies.
Antibody Name:
HRK Antibody (PACO19793)
Antibody SKU:
PACO19793
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human HRK
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19793(HRK Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19793(HRK Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants.
Synonyms:
harakiri, BCL2 interacting protein (contains only BH3 domain)
UniProt Protein Function:
HRK: Promotes apoptosis.Protein type: Membrane protein, integral; ApoptosisChromosomal Location of Human Ortholog: 12q24.22Cellular Component: mitochondrion; integral to membraneMolecular Function: protein bindingBiological Process: apoptosis; positive regulation of apoptosis; positive regulation of protein homooligomerization
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
activator of apoptosis harakiri; death protein 5; BCL2-interacting protein; activator of apoptosis Hrk; neuronal death protein DP5; BH3-interacting domain-containing protein 3; harakiri, BCL2 interacting protein (contains only BH3 domain)
UniProt Protein Name:
Activator of apoptosis harakiri
UniProt Synonym Protein Names:
BH3-interacting domain-containing protein 3; Neuronal death protein DP5
