Human Transforming Growth Factor Beta Receptor 2 Recombinant Protein (CPRT2663)

(No reviews yet) Write a Review
SKU:
CPRT2663
€278

Description

Recombinant Protein DatasheetAntibody MSDS

TGFBR2 Human Recombinant Protein

Name:TGFBR2 Human
Synonyms:AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII, TGFBR-2, TGF-beta receptor type-2, Transforminggrowth factor-beta receptor type II, TGF-beta receptor type II, TGF-beta type II receptor, TbetaR-II, TGFBR2.
Introduction:TGFBR2 is part of the Ser/Thr protein kinase family and the TGFB receptor subfamily. TGFBR2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF–beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys–Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 expression is increased in oral squamous cell carcinoma cells. TGFBR2 attenuates the biological activities of TGF–beta in colorectal cancer. TGFBR2 expression is decreased by IL–1beta while inducingSp3 via NFkappaB.
Description:TGFBR2 Human Recombinant produced in E.Coli is a single, non–glycosylated, polypeptide chain encoding133 amino acids (27–159 a.a.), the extracellular domain of TGFBR2, having a molecular mass of 15.1 kDa.TGFBR2 is purified by proprietary chromatographic techniques
Source:Escherichia Coli.
Pack size:10µg
Physical Appearance:Sterile Filtered White lyophilized (freeze–dried) powder.
Formulation:Lyophilized from a 0.2 ?m filtered solution in buffer containing 150mM NaCl & 50mM sodium phosphate buffer pH–7.5.
Solubility:It is recommended to reconstitute the lyophilized TGFBR2 in sterile 18MΩ–cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized TGFBR2 although stable at room temperature for 3 weeks, should be stored desiccated below –18°C. Upon reconstitution TGFBR2 should be stored at 4°C between 2–7 days and for future use below –18°C. For longterm storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze–thaw cycles.
Purity:Greater than 97.0% as determined by SDS–PAGE.
Amino Acid Sequence:HVQK SVNNDMIVTD NNGAVKFPQL CKFCDVRFST CDNQKSCMSN CSITSICEKP QEVCVAVWRK NDENITLETV CHDPKLPYHD FILEDasPK CIMKEKKKPgETFFMCSCSS DECNDNIIFS EEYNTSNPD
Biological Activity:In ELISA assay, concentrations 0.5–1µg/ml can be used for TGF–beta measurements
Usage:Assay Genie’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Uniprot:P37173

TGFBR2 Human Recombinant Protein - Protein Information

UniProt Protein Function:TGFBR2: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer.
UniProt Protein Details:

Protein type:Oncoprotein; Membrane protein, integral; Protein kinase, TKL; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Kinase, protein; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 3p22

Cellular Component: caveola; cytosol; external side of plasma membrane; integral to membrane; lipid raft; plasma membrane; receptor complex

Molecular Function:ATP binding; glycosaminoglycan binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; protein binding; receptor signaling protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type II; transmembrane receptor protein serine/threonine kinase activity

Biological Process: activation of protein kinase activity; aging; apoptosis; blood vessel development; brain development; common-partner SMAD protein phosphorylation; embryo implantation; embryonic cranial skeleton morphogenesis; embryonic hemopoiesis; gastrulation; gut development; heart development; in utero embryonic development; lens development in camera-type eye; myeloid dendritic cell differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; Notch signaling pathway; organ regeneration; palate development; patterning of blood vessels; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of angiogenesis; positive regulation of B cell tolerance induction; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of NK T cell differentiation; positive regulation of skeletal muscle regeneration; positive regulation of smooth muscle cell proliferation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; receptor-mediated endocytosis; regulation of cell proliferation; regulation of gene expression; response to drug; response to estrogen stimulus; response to glucose stimulus; response to mechanical stimulus; response to nutrient; smoothened signaling pathway; transforming growth factor beta receptor signaling pathway; vasculogenesis; wound healing

Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 6; Esophageal Cancer; Loeys-dietz Syndrome 2

NCBI Summary:This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:P37173
NCBI GenInfo Identifier:116242818
NCBI Gene ID:7048
NCBI Accession:P37173.2
UniProt Secondary Accession:P37173,Q15580, Q6DKT6, Q99474, B4DTV5,
UniProt Related Accession:P37173
Molecular Weight:67,457 Da
NCBI Full Name:TGF-beta receptor type-2
NCBI Synonym Full Names:transforming growth factor beta receptor II
NCBI Official Symbol:TGFBR2  
NCBI Official Synonym Symbols:AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII  
NCBI Protein Information:TGF-beta receptor type-2
UniProt Protein Name:TGF-beta receptor type-2
UniProt Synonym Protein Names:TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II
Protein Family:TGF-beta receptor
UniProt Gene Name:TGFBR2  
UniProt Entry Name:TGFR2_HUMAN
View AllClose

Additional Information

Product type:
Recombinant Protein
Reactivity:
Human
Host Species:
E.Coli
View AllClose

0 Reviews

View AllClose