Human ZFAND5 Recombinant Protein (RPPB5180)
- SKU:
- RPPB5180
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O76080
Description
| Product Name: | Human ZFAND5 Recombinant Protein |
| Product Code: | RPPB5180 |
| Size: | 20µg |
| Species: | Human |
| Target: | ZFAND5 |
| Synonyms: | Zinc Finger, AN1-Type Domain 5, Zinc Finger Protein 216, ZNF216,Zinc Finger A20 Domain-Containing Protein 2, Zinc Finger, A20 Domain Containing2, ZA20D2, AN1-Type Zinc Finger Protein 5, ZFAND5A, AN1-type zinc fingerprotein 5, Zinc finger A20 domain-containing protein 2, Zinc finger protein 216. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ZFAND5 protein solution (0.5mg/ml) containing 20mM Phosphatebuffer saline (pH 8.0), 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAQETNQ TPGPMLCSTG CGFYGNPRTN GMCSVCYKEH LQRQQNSGRMSPMGTASGSN SPTSDSASVQ RADTSLNNCE GAAGSTSEKS RNVPVAALPV TQQMTEMSIS REDKITTPKTEVSEPVVTQP SPSVSQPSTS QSEEKAPELP KPKKNRCFMC RKKVGLTGFD CRCGNLFCGL HRYSDKHNCPYDYKAEAAAK IRKENPVVVA EKIQRI |
Zinc Finger, AN1-Type Domain 5, also known as ZFAND5 is implicated inprotein degradation through the ubiquitin-proteasome system. ZFAND5 performs byanchoring ubiquitinated proteins to the proteasome and takes part inubiquitin-mediated protein degradation during muscle atrophy. Furthemore,ZFAND5 plays a role in the regulation of NF-kappa-B activation as well asapoptosis. ZFAND5 inhibits NF-kappa-B activation as well as tumor necrosisfactor (TNF), IL-1 and TLR4-induced NF-kappa-B activation.
ZFAND5 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 236 amino acids (1-213 a.a) and having a molecularmass of 25.5kDa (Molecular size on SDS-PAGE will appear higher).ZFAND5 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. |
| UniProt Code: | O76080 |
| NCBI GenInfo Identifier: | 156231047 |
| NCBI Gene ID: | 7763 |
| NCBI Accession: | NP_001095890.1 |
| UniProt Secondary Accession: | O76080,A8K484, |
| UniProt Related Accession: | O76080 |
| Molecular Weight: | 23,132 Da |
| NCBI Full Name: | AN1-type zinc finger protein 5 |
| NCBI Synonym Full Names: | zinc finger AN1-type containing 5 |
| NCBI Official Symbol: | ZFAND5�� |
| NCBI Official Synonym Symbols: | ZA20D2; ZNF216; ZFAND5A�� |
| NCBI Protein Information: | AN1-type zinc finger protein 5 |
| UniProt Protein Name: | AN1-type zinc finger protein 5 |
| UniProt Synonym Protein Names: | Zinc finger A20 domain-containing protein 2; Zinc finger protein 216 |
| Protein Family: | AN1-type zinc finger protein |
| UniProt Gene Name: | ZFAND5�� |
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