Human Zinc Ribbon Domain Containing 1 Recombinant Protein (CPRT5182)

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CPRT5182
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Description

Recombinant Protein DatasheetAntibody MSDS

ZNRD1 Human Recombinant Protein

Name:ZNRD1 Human
Synonyms:Zinc Ribbon Domain containing 1, Zinc Ribbon Domain containing , 1, HTEX-6, Rpa12, TEX6, ZR14, DNA-Directed RNA Polymerase I Subunit RPA12, hZR14, RNA Polymerase I Small Specific Subunit Rpa12, tctex-6, Transcription-Associated Zinc Ribbon Protein, RPA12, Zinc Ribbon Domain-containing Protein 1.
Introduction:Zinc Ribbon Domain containing 1 (ZNRD1) is a protein which shows similarity to the Saccharomyces cerevisiae Rpa12p subunit of RNA polymerase I. ZNRD1 contains two potential zinc–bindingmotifs and takes part in regulation of cell proliferation. ZNRD1 is involved in cancer and human immunodeficiency virus progression. Alternate splicingof this gene results in two transcript variants encodingthe same protein. Additional splice variants have been found, but their full–length sequences have not been determined.
Description:ZNRD1 Human Recombinant produced in E.Coli is a single, non–glycosylated polypeptide chain containing 149 amino acids (1–126a.a) and having a molecular mass of 16.3kDa.ZNRD1 is fused to a 23 amino acid His–tag at N–terminus & purified by proprietary chromatographic techniques.
Source:Escherichia Coli.
Pack size:20µg
Physical Appearance:Sterile Filtered clear solution.
Formulation:ZNRD1 protein solution (1mg/ml) containing 20mM Tris–HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Solubility:N/A
Stability:Store at 4°C if entire vial will be used within 2–4 weeks. Store, frozen at –20°C for longer periods of time.For longterm storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greater than 95% as determined by SDS–PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSVMDLA NTCSSFQSDL DFCSDCGSVL PLPGAQDTVT CIRCGFNINV RDFEGKVVKT SVVFHQLGTA MPMSVEEGPE CQGPVVDRRC PRCGHEGMAY HTRQMRSADE GQTVFYTCTN CKFQEKEDS
Biological Activity:N/A
Usage:Assay Genie’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Uniprot:Q9P1U0

ZNRD1 Human Recombinant Protein - Protein Information

UniProt Protein Function:ZNRD1: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
UniProt Protein Details:

Protein type:Transcription initiation complex; Transferase; Nucleolus

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: DNA-directed RNA polymerase I complex; nucleoplasm

Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter

NCBI Summary:This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:Q9P1U0
NCBI GenInfo Identifier:71649339
NCBI Gene ID:30834
NCBI Accession:Q9P1U0.1
UniProt Secondary Accession:Q9P1U0,Q1RMP0, Q5TM50, Q791N7, Q1XHV8, Q6MFY5,
UniProt Related Accession:Q9P1U0
Molecular Weight:13,904 Da
NCBI Full Name:DNA-directed RNA polymerase I subunit RPA12
NCBI Synonym Full Names:zinc ribbon domain containing 1
NCBI Official Symbol:ZNRD1  
NCBI Official Synonym Symbols:TEX6; ZR14; HTEX6; Rpa12; hZR14; HTEX-6; TCTEX6; tctex-6  
NCBI Protein Information:DNA-directed RNA polymerase I subunit RPA12
UniProt Protein Name:DNA-directed RNA polymerase I subunit RPA12
UniProt Synonym Protein Names:Zinc ribbon domain-containing protein 1
UniProt Gene Name:ZNRD1  
UniProt Entry Name:RPA12_HUMAN
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Additional Information

Product type:
Recombinant Protein
Reactivity:
Human
Host Species:
E.Coli
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