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KDELR2 Antibody (PACO00996)

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SKU:
PACO00996
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€319

Description

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KDELR2 Antibody (PACO00996)

The KDELR2 Polyclonal Antibody (PACO00996) is an essential tool for researchers studying the role of KDELR2, a key protein involved in the quality control of protein trafficking within the cell. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in applications such as Western blot.KDELR2, also known as KDEL receptor 2, plays a crucial role in the retrieval of ER-resident proteins that have escaped to the Golgi apparatus, ensuring proper protein folding and quality control.

Dysregulation of KDELR2 has been implicated in various diseases such as neurodegenerative disorders and cancer, making it an attractive target for further investigation.By utilizing the KDELR2 Polyclonal Antibody, researchers can effectively detect and analyze KDELR2 protein levels in different cell types, providing valuable insights into its function in various physiological and pathological conditions. This antibody is an indispensable tool for studies in cell biology, protein trafficking, and disease research.

Antibody Name:KDELR2 Antibody
Antibody SKU:PACO00996
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the Internal region of human KDEL Receptor 2.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:KDELR2; ERD2.2; ER lumen protein retaining receptor 2; ERD2-like protein 1; ELP-1; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2
UniProt Protein Function:KDELR2: Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L. Belongs to the ERD2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 7p22.1Cellular Component: cis-Golgi network; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; integral to membraneMolecular Function: KDEL sequence bindingBiological Process: intracellular protein transport; protein retention in ER; vesicle-mediated transport
UniProt Protein Details:
NCBI Summary:Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:P33947
NCBI GenInfo Identifier:462018
NCBI Gene ID:11014
NCBI Accession:P33947.1
UniProt Secondary Accession:P33947,Q6IPC5, Q96E30, A4D2P4
UniProt Related Accession:P33947
Molecular Weight:21,242 Da
NCBI Full Name:ER lumen protein-retaining receptor 2
NCBI Synonym Full Names:KDEL endoplasmic reticulum protein retention receptor 2
NCBI Official Symbol:KDELR2  
NCBI Official Synonym Symbols:ELP-1; ERD2.2  
NCBI Protein Information:ER lumen protein-retaining receptor 2
UniProt Protein Name:ER lumen protein-retaining receptor 2
UniProt Synonym Protein Names:ERD2-like protein 1; ELP-1; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2
Protein Family:ER lumen protein-retaining receptor
UniProt Gene Name:KDELR2  
UniProt Entry Name:ERD22_HUMAN

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