The Mia2 Antibody (PAC056026) is a valuable tool for researchers studying Mia2, a protein involved in cell cycle regulation and cancer progression. This polyclonal antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in various applications, including Western blotting. By binding specifically to Mia2, this antibody enables precise detection and analysis of Mia2 expression in different cell types, making it an ideal choice for studies in cancer biology and cell signaling pathways.
Mia2, also known as differentially expressed in adenocarcinoma of the lung 2, plays a crucial role in promoting cell proliferation and survival, making it a potential therapeutic target for cancer treatment. Understanding the function and regulation of Mia2 is essential for developing effective strategies to inhibit its activity and prevent tumor growth. With its high specificity and sensitivity, the Mia2 Antibody is a valuable tool for researchers investigating the role of Mia2 in cancer development and progression.
Antibody Name:
MIA2 Antibody (PACO56026)
Antibody SKU:
PACO56026
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Melanoma inhibitory activity protein 2 protein (178-354AA)
IHC image of PACO56026 diluted at 1:300 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of PACO56026 diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Isoform 1 plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum. Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity).
Synonyms:
Melanoma inhibitory activity protein 2, MIA2
UniProt Protein Function:
MIA2: May play a role in the pathophysiology of liver disease and may serve as a marker of liver damage. Belongs to the MIA/OTOR family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 14q13.2Cellular Component: extracellular regionBiological Process: cholesterol homeostasis
