Mouse IL 15 Recombinant Protein (RPPB0588)
- SKU:
- RPPB0588
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P48346
- Research Area:
- Cytokines
Description
| Product Name: | Mouse IL 15 Recombinant Protein |
| Product Code: | RPPB0588 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | IL 15 |
| Synonyms: | IL-15, MGC9721, Interleukin-15, Il15, AI503618. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The mouse IL-15 protein solution contains PBS, pH-7.4 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMNW IDVRYDLEKI ESLIQSIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILHEYSNMTLNET VRNVLYLANS TLSSNKNVAE SGCKECEELE EKTFTEFLQS FIRIVQMFIN TS |
| Biological Activity: | Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is < 1 ng/ml, corresponding to a specific activity of 1,000,000IU/mg. |
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
Interleukin-15 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 152 amino acids (49-162 a.a.) and having a molecular mass of 17.6 kDa. The IL-15 is fused to a 37 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL15: Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Cell cycle regulation; Cytokine; Secreted, signal peptide Cellular Component: nucleoplasm; extracellular space; cell surface; cytoplasm; extracellular region Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine activity Biological Process: positive regulation of interleukin-17 production; NK T cell proliferation; positive regulation of natural killer cell proliferation; positive regulation of immune response; negative regulation of smooth muscle cell proliferation; cell maturation; signal transduction; lymph node development; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of natural killer cell differentiation; extrathymic T cell selection; natural killer cell differentiation; positive regulation of cell proliferation; immune response; regulation of T cell differentiation; positive regulation of T cell proliferation; regulation of defense response to virus by host; hyaluronan metabolic process |
| UniProt Code: | P48346 |
| NCBI GenInfo Identifier: | 1352449 |
| NCBI Gene ID: | 16168 |
| NCBI Accession: | P48346.1 |
| UniProt Related Accession: | P48346 |
| Molecular Weight: | 18,593 Da |
| NCBI Full Name: | Interleukin-15 |
| NCBI Synonym Full Names: | interleukin 15 |
| NCBI Official Symbol: | Il15�� |
| NCBI Official Synonym Symbols: | IL-15; AI503618�� |
| NCBI Protein Information: | interleukin-15 |
| UniProt Protein Name: | Interleukin-15 |
| UniProt Gene Name: | Il15�� |
| UniProt Entry Name: | IL15_MOUSE |
