The NR6A1 Polyclonal Antibody (PACO10927) from Assay Genie is a vital tool for researchers studying the NR6A1 gene, a key transcription factor involved in various biological processes such as cell differentiation and embryonic development. This antibody, generated using rabbits, shows high specificity and sensitivity towards NR6A1 in human samples, making it suitable for Western blot applications.The NR6A1 protein, also known as germ cell nuclear factor (GCNF), plays a crucial role in maintaining the pluripotency of embryonic stem cells and regulating gene expression during development.
Dysregulation of NR6A1 has been linked to various diseases, including infertility, cancer, and neurological disorders, making it a promising target for therapeutic interventions.By targeting NR6A1 with the PACO10927 antibody, researchers can better understand the role of this transcription factor in disease pathology and potentially uncover novel treatment strategies. This antibody is a valuable asset for studies in developmental biology, reproductive medicine, and cancer research, providing insights into the molecular mechanisms underlying these complex conditions.
nuclear receptor subfamily 6, group A, member 1;NR6A1;GCNF;GCNF1;NR61;RTR ;
UniProt Protein Function:
NR6A1: Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis. Homodimer. Interacts with UIMC1. Shows highest expression in the germ cells of the adult testis. Belongs to the nuclear hormone receptor family. NR6 subfamily. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Nuclear receptor; DNA-bindingChromosomal Location of Human Ortholog: 9q33.3Cellular Component: nucleoplasm; nucleus; transcription factor complexMolecular Function: DNA binding; ligand-dependent nuclear receptor activity; protein homodimerization activity; sequence-specific DNA bindingBiological Process: cell proliferation; gamete generation; negative regulation of transcription from RNA polymerase II promoter; spermatogenesis; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]
