The KDR Polyclonal Antibody (CAB11127) is a valuable tool for researchers studying KDR, also known as vascular endothelial growth factor receptor 2 (VEGFR2). This cell surface receptor plays a crucial role in angiogenesis, the process of forming new blood vessels from existing ones. The antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.By binding specifically to the KDR protein, this antibody enables the detection and analysis of KDR expression in various cell types.
This makes it an ideal choice for studies in vascular biology, cancer research, and other fields where angiogenesis is a key process. Understanding the function of KDR is essential for developing strategies to target angiogenesis in diseases like cancer, diabetic retinopathy, and cardiovascular disorders.Overall, the KDR Polyclonal Antibody (CAB11127) provides researchers with a reliable tool for investigating the role of KDR in angiogenesis and its potential as a therapeutic target in various diseases.
Product Name:
VEGF Receptor 2 Rabbit Polyclonal Antibody
SKU:
CAB11127
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1147-1356 of human VEGF Receptor 2 (NP_002244.1).
Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Early endosome, Endoplasmic reticulum, Nucleus, Secreted, Single-pass type I membrane protein.
Calculated MW:
152kDa
Observed MW:
210kDa/230kDa
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
Purification Method:
Affinity purification
Gene ID:
3791
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using VEGF Receptor 2 Rabbit pAb (CAB11127) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
