The Polq Antibody (PACO3362) is a specialized tool for researchers studying the DNA repair enzyme Polq. This rabbit polyclonal antibody is highly specific for human samples and is validated for use in various applications, including Western blotting. By binding to the Polq protein, this antibody allows for the detection and analysis of Polq expression in different cell types, making it an essential tool for studies in genetics, cancer research, and molecular biology.Polq is a key player in DNA repair processes and is involved in maintaining genomic stability.
Dysregulation of Polq has been implicated in various diseases, including cancer and neurodevelopmental disorders. By studying the function and regulation of Polq, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets. The Polq Antibody is a valuable resource for advancing our understanding of DNA repair mechanisms and their implications for human health.
Antibody Name:
POLQ Antibody
Antibody SKU:
PACO03362
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the N-terminal region of human DNA pol Theta.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
POLQ; POLH; DNA polymerase theta; DNA polymerase eta
UniProt Protein Function:
POLQ: Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links. Belongs to the DNA polymerase type-A family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: DNA repair, damage; Transferase; EC 2.7.7.7Chromosomal Location of Human Ortholog: 3q13.33Cellular Component: nucleoplasmMolecular Function: DNA-directed DNA polymerase activity; damaged DNA binding; ATP binding; single-stranded DNA-dependent ATPase activityBiological Process: DNA repair; DNA-dependent DNA replication
