Based on the information in the provided URL, the PPAP2C Polyclonal Antibody (PACO18808) is a valuable tool for researchers studying the PPAP2C protein. PPAP2C, also known as lipid phosphate phosphohydrolase 3 (LPP3), is a key enzyme involved in the regulation of lipid metabolism and cellular signaling pathways.This polyclonal antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By specifically binding to the PPAP2C protein, this antibody enables researchers to detect and analyze PPAP2C expression in different cell types, facilitating studies in lipid metabolism, cell signaling, and related fields.
The PPAP2C Polyclonal Antibody is particularly useful for investigations in areas such as cancer biology, lipid signaling pathways, and metabolic disorders, where PPAP2C's functions are of great interest. By gaining a better understanding of the role of PPAP2C in cellular processes, researchers can potentially uncover new therapeutic targets and develop novel treatments for diseases associated with dysregulated lipid metabolism and signaling.
Antibody Name:
PPAP2C Antibody (PACO18808)
Antibody SKU:
PACO18808
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human PPAP2C
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse trachea tissue, Primary antibody: PACO18808(PPAP2C Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
Background:
The protein encoded by this gene is a member of the phosphatidic acid, phosphatase (PAP) family. PAPs convert phosphatidic acid, to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid, phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms:
Phosphatidic acid, phosphatase type 2C
UniProt Protein Function:
PPAP2C: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P. Belongs to the PA-phosphatase related phosphoesterase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Lipid Metabolism - ether lipid; Motility/polarity/chemotaxis; Membrane protein, multi-pass; EC 3.1.3.4; Lipid Metabolism - glycerolipid; Phosphatase, lipid; Membrane protein, integral; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - sphingolipidChromosomal Location of Human Ortholog: 19p13Cellular Component: integral to plasma membrane; membrane; plasma membraneMolecular Function: lipid phosphatase activity; phosphoprotein phosphatase activity; protein binding; sphingosine-1-phosphate phosphatase activityBiological Process: phospholipid dephosphorylation; phospholipid metabolic process; signal transduction; sphingolipid biosynthetic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
