The PSMB11 Polyclonal Antibody (PAC011531) is a valuable tool for researchers studying the PSMB11 protein, a key component of the proteasome complex involved in protein degradation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By specifically binding to PSMB11, researchers can accurately detect and analyze the protein in a variety of cell types, making it an essential tool for investigations in areas such as cell biology and drug development.PSMB11 is known for its role in regulating protein turnover and degradation within cells, playing a crucial role in maintaining cellular homeostasis and overall cell health.
Dysregulation of the proteasome complex, including PSMB11, has been linked to various diseases, including cancer and neurodegenerative disorders. Therefore, understanding the function and activity of PSMB11 is vital for developing targeted therapies and treatments for these conditions.By utilizing the PSMB11 Polyclonal Antibody, researchers can gain valuable insights into the role of PSMB11 in cellular processes and disease pathology, ultimately paving the way for innovative discoveries and advancements in the field of biomedical research.
PSMB11: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T cells. Belongs to the peptidase T1B family.Protein type: EC 3.4.25.1; Protease; Proteasome complexChromosomal Location of Human Ortholog: 14q11.2Cellular Component: cytosolMolecular Function: peptidase activityBiological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; proteolysis; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
UniProt Protein Details:
NCBI Summary:
Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008]
