Anti-PTH Antibody (MACO0572)
- SKU:
- MACO0572
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Application:
- ELISA
- Antibody type:
- Monoclonal Antibody
- Conjugation:
- Unconjugated
Description
| Product Name: | Anti-PTH Antibody |
| Product Sku: | MACO0572 |
| Size: | 50ug |
| Host Species: | Mouse |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant PTH Protein |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%,Protein G purified |
| Clonality: | Monoclonal |
| Isotype: | IgG1 |
| Conjugate: | Non-conjugated |
| Background: | Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids, yet effective hormone-receptor interaction requires solely the 34-N-terminal amino acids. While PTH acts to increase the concentration of ionic calcium (Ca2+) in the blood, calcitonin, a hormone produced by the parafollicular cells (C cells) of the thyroid gland, acts to decrease ionic calcium concentration. PTH essentially acts to increase the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor, which is present at high levels in bone and kidney, and the parathyroid hormone 2 receptor, which is present at high levels in the central nervous system, pancreas, testis, and placenta.PTH half-life is approximately 4 minutes. It has a molecular mass of approximately 9.4 kDa. |
| Synonyms: | Parathyroid hormone, PTH |
| UniProt Protein Function: | PTH: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Belongs to the parathyroid hormone family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Hormone; Apoptosis Chromosomal Location of Human Ortholog: 11p15.3-p15.1 Cellular Component: extracellular space; extracellular region Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; type 1 parathyroid hormone receptor binding; parathyroid hormone receptor binding; peptide hormone receptor binding; hormone activity Biological Process: response to drug; transcription from RNA polymerase II promoter; positive regulation of signal transduction; induction of apoptosis by hormones; positive regulation of glycogen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of bone mineralization; G-protein signaling, adenylate cyclase activating pathway; Rho protein signal transduction; cellular calcium ion homeostasis; positive regulation of glucose import; G-protein coupled receptor protein signaling pathway; cAMP metabolic process; response to vitamin D; response to cadmium ion; response to ethanol; cell-cell signaling; regulation of gene expression; positive regulation of cAMP biosynthetic process; response to lead ion; positive regulation of transcription from RNA polymerase II promoter; skeletal development; bone resorption Disease: Hypoparathyroidism, Familial Isolated |
| NCBI Summary: | The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01270 |
| NCBI GenInfo Identifier: | 131547 |
| NCBI Gene ID: | 5741 |
| NCBI Accession: | P01270.1 |
| UniProt Secondary Accession: | P01270,Q4VB48, Q9UD38, |
| UniProt Related Accession: | P01270 |
| Molecular Weight: | 12,861 Da |
| NCBI Full Name: | Parathyroid hormone |
| NCBI Synonym Full Names: | parathyroid hormone |
| NCBI Official Symbol: | PTH |
| NCBI Official Synonym Symbols: | PTH1 |
| NCBI Protein Information: | parathyroid hormone; parathyrin; prepro-PTH; parathormone; parathyroid hormone 1; preproparathyroid hormone |
| UniProt Protein Name: | Parathyroid hormone |
| UniProt Synonym Protein Names: | Parathormone; Parathyrin |
| Protein Family: | Parathyroid hormone |
| UniProt Gene Name: | PTH |
| UniProt Entry Name: | PTHY_HUMAN |
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